http://www.cnr.it/ontology/cnr/individuo/prodotto/ID315576
DAC-driven Integrative Network Regulation and Pathway Coordination in Breast Cancer (Abstract/Comunicazione in rivista)
- Type
- Label
- DAC-driven Integrative Network Regulation and Pathway Coordination in Breast Cancer (Abstract/Comunicazione in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Alternative label
Mariama El Baroudi, Dario La Sala, Caterina Cinti, Enrico Capobianco (2013)
DAC-driven Integrative Network Regulation and Pathway Coordination in Breast Cancer
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Mariama El Baroudi, Dario La Sala, Caterina Cinti, Enrico Capobianco (literal)
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#curatori
- Note
- Comunicazione (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Laboratory of Integrative Systems Medicine, Institute of Clinical Physiology, CNR, Italy
Dept. Biomedical Science, University of Palermo, Italy
Institue of Clinical Physiology, CNR, UOS Siena, Italy
Laboratory of Integrative Systems Medicine, Institute of Clinical Physiology, CNR, Italy & Center for Computational Science, Miller School of Medicine, University of Miami, (literal)
- Titolo
- DAC-driven Integrative Network Regulation and Pathway Coordination in Breast Cancer (literal)
- Abstract
- Epigenetic variation represents a mechanism of regulation for genes expressed in different cancer histotypes. We considered breast cancer, and investigated differential expression following treatment with the 5- Aza-2'-deoxycytidine or DAC, a demethylating agent. Several oncogenic signalling pathways altered upon DAC treatment were detected with significant enrichment, and a regulatory map integrating Transcription Factors and microRNAs was derived. The ultimate goal is deciphering the potential molecular mechanisms induced by DAC therapy in MCF7 cells. (literal)
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