DAC-driven Integrative Network Regulation and Pathway Coordination in Breast Cancer (Abstract/Comunicazione in rivista)

Type
Label
  • DAC-driven Integrative Network Regulation and Pathway Coordination in Breast Cancer (Abstract/Comunicazione in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Alternative label
  • Mariama El Baroudi, Dario La Sala, Caterina Cinti, Enrico Capobianco (2013)
    DAC-driven Integrative Network Regulation and Pathway Coordination in Breast Cancer
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mariama El Baroudi, Dario La Sala, Caterina Cinti, Enrico Capobianco (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#curatori
  • Cinti Caterina (literal)
Note
  • Comunicazione (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Laboratory of Integrative Systems Medicine, Institute of Clinical Physiology, CNR, Italy Dept. Biomedical Science, University of Palermo, Italy Institue of Clinical Physiology, CNR, UOS Siena, Italy Laboratory of Integrative Systems Medicine, Institute of Clinical Physiology, CNR, Italy & Center for Computational Science, Miller School of Medicine, University of Miami, (literal)
Titolo
  • DAC-driven Integrative Network Regulation and Pathway Coordination in Breast Cancer (literal)
Abstract
  • Epigenetic variation represents a mechanism of regulation for genes expressed in different cancer histotypes. We considered breast cancer, and investigated differential expression following treatment with the 5- Aza-2'-deoxycytidine or DAC, a demethylating agent. Several oncogenic signalling pathways altered upon DAC treatment were detected with significant enrichment, and a regulatory map integrating Transcription Factors and microRNAs was derived. The ultimate goal is deciphering the potential molecular mechanisms induced by DAC therapy in MCF7 cells. (literal)
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