http://www.cnr.it/ontology/cnr/individuo/prodotto/ID315496

Prenatal diagnosis and epidemiology of multicystic kidney dysplasia in Europe (Articolo in rivista)

Type

Label

Prenatal diagnosis and epidemiology of multicystic kidney dysplasia in Europe (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Winding, Louise; Loane, Maria; Wellesley, Diana; Addor, Marie-Claude; Arriola, Larraitz; Bakker, Marian K.; Bianchi, Fabrizio; Calzolari, Elisa; Gatt, Miriam; Haeusler, Martin; Lelong, Nathalie; Mullaney, Carmel; Scarano, Gioacchino; Tucker, David; Wiesel, Awi; Garne, Ester (2014)
Prenatal diagnosis and epidemiology of multicystic kidney dysplasia in Europe
in Prenatal diagnosis (Print); JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012, New York (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Winding, Louise; Loane, Maria; Wellesley, Diana; Addor, Marie-Claude; Arriola, Larraitz; Bakker, Marian K.; Bianchi, Fabrizio; Calzolari, Elisa; Gatt, Miriam; Haeusler, Martin; Lelong, Nathalie; Mullaney, Carmel; Scarano, Gioacchino; Tucker, David; Wiesel, Awi; Garne, Ester (literal)

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Hosp Lillebaelt; University of Ulster; Princess Anne Hosp; University of Lausanne; University of Barcelona; University of Groningen; CNR Inst Clin Physiol; G Monasterio Tuscany Fdn; University Ferrara Hospital; Directorate Hlth Informat & Res; Medical University of Graz; Centre National de la Recherche Scientifique (CNRS); HSE South South Eas; Regione Campania; PUBL Hlth; Johannes Gutenberg University of Mainz (literal)

Titolo

Prenatal diagnosis and epidemiology of multicystic kidney dysplasia in Europe (literal)

Abstract

OBJECTIVES:The aim of this study is to describe the prenatal diagnosis and epidemiology of multicystic kidney dysplasia (MCKD). METHODS:The study is based on routinely collected data from a European database of major congenital anomalies including 13 registries with cases born in 1997-2006 and covering 1 458 552 births. RESULTS:There were 601 MCKD cases giving an overall prevalence of 4.12 per 10 000 births with regional variation. In live births, 87% of cases had an isolated renal anomaly and 13% had associated major nonrenal anomalies (chromosomal, syndrome or other major anomalies). For the cases with isolated renal anomalies, 51/386 (11%) and 7/386 (2%) choose to terminate the pregnancy or resulted in an intrauterine fetal death, respectively. The prenatal detection rate was 88% in both unilateral and bilateral cases. Birth outcome differed with 92% of unilateral MCKD cases being liveborn compared with 33% of bilateral MCKD cases. For unilateral MCKD cases, 84% had an isolated renal anomaly compared with 51% of bilateral MCKD cases (p < 0.001). CONCLUSIONS:Cases with unilateral MCKD are mainly liveborn, and only 16% have associated major malformations or a syndrome. Cases with bilateral MCKD are often associated with nonrenal major congenital anomalies or part of a syndrome, and only one third of bilateral MCKD cases in this study were liveborn. Prenatal detection rate of MCKD was high for both unilateral and bilateral cases. © 2014 John Wiley & Sons, Ltd. (literal)

Editore