Use of in vitro models to identify biologically relevant phenolic forms from olive mill wastewater extracts (Contributo in atti di convegno)

Type
Label
  • Use of in vitro models to identify biologically relevant phenolic forms from olive mill wastewater extracts (Contributo in atti di convegno) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Mario G. Ferruzzi, Angela Cardinali (2012)
    Use of in vitro models to identify biologically relevant phenolic forms from olive mill wastewater extracts
    in Olives, Virgin Olive Oil and Olive Mill Waste Water: Sustainable Management and Development, Bari, 12/10/2012
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mario G. Ferruzzi, Angela Cardinali (literal)
Pagina inizio
  • 6 (literal)
Pagina fine
  • 7 (literal)
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  • Convegno internazionale organizzato nell'ambito del progetto: Utilization of biophenols from Olea Europea products - Olives, virgin olive oil and olive mill wastewater- BIO-OLEA; (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 2 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Mario G. Ferruzzi, Department of Food Science, Purdue University, West Lafayette, IN, USA Angela Cardinali ISPA-CNR (literal)
Titolo
  • Use of in vitro models to identify biologically relevant phenolic forms from olive mill wastewater extracts (literal)
Abstract
  • The objective of the present study was to use an in vitro digestion/Caco-2 human intestinal cell model to assess the bioaccessibility and intestinal absorption/metabolism of verbascosides from a partially purified OMWW extract. In vitro digestive recoveries (bioaccessibility) of verbascoside and isoverbascoside following simulated gastro/intestinal digestion, were found to be 35.5 ± 0.55% and 9.2 ± 0.94% respectively. Accumulation of verbascoside and isoverbascoside from OMWW extract by Caco-2 monolayers was found to be linear between 10 and 100?M and rapid with peak accumulation occurring by 30min. Verbascoside was found to be metabolized by Caco-2 primarily by O-methylation generating two distinct metabolite forms with m/z of 634.5 and 353. Combined, these data support the notion that verbascosides from OMWW extract are bioaccessible and should be considered biologically relevant phenolic forms from OMWW. (literal)
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