Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma. (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/all.12547. (literal)

Alternative label

• Sorbello V, Ciprandi G, Di Stefano A, Massaglia GM, Favatà G, Conticello S, Malerba M, Folkerts G, Profita M, Rolla G, Ricciardolo FL. (2015)
  Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma.
  in Allergy
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sorbello V, Ciprandi G, Di Stefano A, Massaglia GM, Favatà G, Conticello S, Malerba M, Folkerts G, Profita M, Rolla G, Ricciardolo FL. (literal)

Pagina inizio

• 236 (literal)

Pagina fine

• 240 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 70 (literal)

Rivista

• Allergy (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 4 (literal)

Note

• ubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Clinical and Biological Sciences, University of Torino, Torino IRCCS-AOU San Martino, Genova Laboratorio di Citoimmunopatologia dell'Apparato Cardio Respiratorio, Fondazione Salvatore Maugeri, IRCCS, Veruno, Novara; Division of Respiratory Disease, San Luigi Hospital, Orbassano Division of Ear, Nose and Throat, Department of Clinical and Biological Sciences, University of Torino, Torino Department of Internal Medicine, University of Brescia, Brescia, Italy Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands Istituto di Biomedicina e Immunologia Molecolare, CNR, Palermo Allergologia ed Immunologia Clinica, Ospedale Ordine Mauriziano 'Umberto I', University of Torino, Torino, Italy (literal)

Titolo

• Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma. (literal)

Abstract

• Severe asthma (SA) is associated with neutrophil recruitment and T helper (TH) 17 chemokine overexpression in bronchial biopsies. We aimed to evaluate IL-17A and IL-17F expression in nasal/bronchial lamina propria of atopic mild-to-severe asthmatics and controls in relation to neutrophilia and asthma exacerbations. Cryostat sections of nasal/bronchial biopsies obtained from 14 SA and 14 mild asthma (MA) stable atopic patients with rhinitis, and seven healthy controls were analyzed by immunohistochemistry for neutrophils, IL-17A and IL-17F expression. Atopic SA showed an increase in asthma exacerbations number, IL-17F and IL-17A expression in nasal/bronchial lamina propria compared to MA and controls, and a higher expression of bronchial neutrophils in SA compared to MA and controls. In all asthmatics, significant relationships were found between bronchial IL-17F and neutrophils/FEV1, nasal IL-17F and bronchial neutrophil/IL-17 markers and between the latter and exacerbations, suggesting that nasal IL-17F might be informative on bronchial IL17-driven neutrophilia in atopic SA. (literal)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Modelli ex vivo/in vitro per lo studio dell'immunopatologia e della farmacologia nelle pneumopatie (ME.P01.014.007) (Modulo)

Autore CNR

• MIRELLA PROFITA (Persona)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Modelli ex vivo/in vitro per lo studio dell'immunopatologia e della farmacologia nelle pneumopatie (ME.P01.014.007) (Modulo)

Autore CNR di

• MIRELLA PROFITA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Allergy (Rivista)