Effect of subcutaneous desferrioxamine on iron balance in young thalassemia major patients. (Articolo in rivista)

Type
Label
  • Effect of subcutaneous desferrioxamine on iron balance in young thalassemia major patients. (Articolo in rivista) (literal)
Anno
  • 1983-01-01T00:00:00+01:00 (literal)
Alternative label
  • De Virgiliis, S; Cossu, P; Toccafondi, C; Sanna, G; Frau, F; Lobrano, R; Cornacchia, G; Nucaro, A; Loi, A; Bertolino, F; Cao, A (1983)
    Effect of subcutaneous desferrioxamine on iron balance in young thalassemia major patients.
    in The American journal of pediatric hematology/oncology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • De Virgiliis, S; Cossu, P; Toccafondi, C; Sanna, G; Frau, F; Lobrano, R; Cornacchia, G; Nucaro, A; Loi, A; Bertolino, F; Cao, A (literal)
Pagina inizio
  • 73 (literal)
Pagina fine
  • 77 (literal)
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  • 5 (literal)
Rivista
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  • 1 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • Università di Cagliari IRGB-CNR- Cagliari (literal)
Titolo
  • Effect of subcutaneous desferrioxamine on iron balance in young thalassemia major patients. (literal)
Abstract
  • In this study we evaluated the effect of 1-year, subcutaneous desferrioxamine daily infusion on iron balance in 23 thalassemia major children, aged 8-74 months, with transfusional iron accumulation less than 3.8 g at the outset of the trial. Statistical analysis showed a significant correlation between transfusional iron accumulation and percentage of transfusional iron eliminated. Confidence limits analysis of these data indicated that over 3.5 g of transfusional iron load, 95% of the patients may achieve balance. The appropriate time to begin desferrioxamine infusion, therefore, seems to be after about 30 transfusions of packed red blood cells when iron accumulation of approximately 3 g is reached. As we found a statistically significant correlation between transfusional iron eliminated and serum ferritin levels, the evaluation of serum ferritin alone can also predict when balance can be obtained. (literal)
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