http://www.cnr.it/ontology/cnr/individuo/prodotto/ID312508

Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy: a population-based study in six European regions (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy: a population-based study in six European regions (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1111/1471-0528.13143 (literal)

Alternative label

RA Charlton,a S Jordan,b A Pierini,c E Garne,d AJ Neville,e AV Hansen,d R Gini,f D Thayer,g K Tingay,g A Puccini,h HJ Bos,i AM Nybo Andersen,j M Sinclair,k H Dolk,l LTW de Jong-van den Bergi (2014)
Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy: a population-based study in six European regions
in BJOG (Oxford. Online); John Wiley & Sons Ltd., Chichester (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

RA Charlton,a S Jordan,b A Pierini,c E Garne,d AJ Neville,e AV Hansen,d R Gini,f D Thayer,g K Tingay,g A Puccini,h HJ Bos,i AM Nybo Andersen,j M Sinclair,k H Dolk,l LTW de Jong-van den Bergi (literal)

Pagina inizio

1 (literal)

Pagina fine

11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.ncbi.nlm.nih.gov/pubmed/25352424 (literal)

Rivista

BJOG (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

a Department of Pharmacy and Pharmacology, University of Bath, Bath, UK b Department of Nursing, College of Human and Health Sciences, Swansea University, Swansea, UK c Institute of Clinical Physiology - National Research Council (IFC-CNR), Pisa, Italy d Paediatric Department, Hospital Lillebaelt, Kolding, Denmark e IMER (Emilia Romagna Registry of Birth Defects), Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy f Agenzia Regionale di Sanità Della Toscana, Florence, Italy g Centre for Health Information, Research and Evaluation, Swansea University, Swansea, UK h Drug Policy Service, Emilia Romagna Region Health Authority, Bologna, Italy i Pharmacoepidemiology and Pharmacoeconomics Unit, Department of Pharmacy, University of Groningen, Groningen, the Netherlands j Department of Public Health, University of Copenhagen, Copenhagen, Denmark k Maternal, Fetal and Infant Research Centre, l Institute of Nursing, University of Ulster, Ulster, UK (literal)

Titolo

Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy: a population-based study in six European regions (literal)

Abstract

Objective To explore the prescribing patterns of selective serotonin reuptake inhibitors (SSRIs) before, during and after pregnancy in six European population-based databases. Design Descriptive drug utilisation study. Setting Six electronic healthcare databases in Denmark, the Netherlands, Italy (Emilia Romagna/Tuscany), Wales and the rest of the UK. Population All women with a pregnancy ending in a live or stillbirth starting and ending between 2004 and 2010. Methods A common protocol was implemented across databases to identify SSRI prescriptions issued (UK) or dispensed (non-UK) in the year before, during or in the year following pregnancy. Main outcome measures The percentage of deliveries in which the woman received an SSRI prescription in the year before, during or in the year following pregnancy. We also compared the choice of SSRIs and changes in prescribing over the study period. Results In total, 721 632 women and 862 943 deliveries were identified. In the year preceding pregnancy, the prevalence of SSRI prescribing was highest in Wales [9.6%; 95% confidence interval (CI95), 9.4-9.8%] and lowest in Emilia Romagna (3.3%; CI95, 3.2-3.4%). During pregnancy, SSRI prescribing had dropped to between 1.2% (CI95, 1.1-1.3%) in Emilia Romagna and 4.5% (CI95, 4.3-4.6%) in Wales. The higher UK pre-pregnancy prescribing rates resulted in higher first trimester exposures. After pregnancy, SSRI prescribing increased most rapidly in the UK. Paroxetine was more commonly prescribed in the Netherlands and Italian regions than in Denmark and the UK. Conclusions The higher SSRI prescribing rates in the UK, compared with other European regions, raise questions about differences in the prevalence and severity of depression and its management in pregnancy across Europe. (literal)

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