Multiple Regulatory Regions and Tissue Specific Transcription Initiation Mediate the Expression of NEMO/IKKg Gene (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Multiple Regulatory Regions and Tissue Specific Transcription Initiation Mediate the Expression of NEMO/IKKg Gene (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• F. Fusco, V. Mercadante, M.G. Miano and M.V. Ursini. (2006)
  Multiple Regulatory Regions and Tissue Specific Transcription Initiation Mediate the Expression of NEMO/IKKg Gene
  in Gene (Amst.); Elsevier, New York (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• F. Fusco, V. Mercadante, M.G. Miano and M.V. Ursini. (literal)

Pagina inizio

• 99 (literal)

Pagina fine

• 107 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 383 (literal)

Rivista

• Gene (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Genetics and Biophysics, Naples, Italy. (literal)

Titolo

• Multiple Regulatory Regions and Tissue Specific Transcription Initiation Mediate the Expression of NEMO/IKKg Gene (literal)

Abstract

• NEMO/IKK? gene, which is responsible of two allelic diseases in human, EDA-ID and IP, encodes for a protein with a central regulatory role in the activation of the NF-kB pathway. We here provide insights into the molecular mechanism governing NEMO/IKK? expression. We mapped 4 distinctive NEMO/IKK? transcription start sites each corresponding to an alternative first exon, controlled by two conserved promoters. A distal promoter, named promoter A, located 10 kb upstream of the coding region and a proximal promoter, promoter B, with strong bi-directional activity driving also the transcription of G6PD gene in the opposite direction. The promoter B is housekeeping, it is embedded in a CpG island, required for proper expression and it is down-regulated by methylation. The promoter A is active in cells of hepatic origin and it directs transcription of the main NEMO/IKK? 5? UTR alternative transcript in liver, which starts at a tissue-specific site. Qualitative and quantitative expression analysis revealed that each NEMO/IKK? 5? UTR alternative transcript has different expression profiles indicating that the control of NEMO/IKK? expression is mediated through tissue-specific transcription initiation sites and multiple regulatory regions. © 2006 Elsevier B.V. All rights reserved. (literal)

Editore

• Elsevier (Editore)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Variabilità del genoma ed alterazioni genetiche nell'uomo e loro impatto biologico - (SV.P13.004.001) (Modulo)

Autore CNR

• MARIA GIUSEPPINA MIANO (Persona)
• MATILDE URSINI (Persona)
• FRANCESCA FUSCO (Unità di personale interno)

Incoming links:

Autore CNR di

• MARIA GIUSEPPINA MIANO (Persona)
• MATILDE URSINI (Persona)
• FRANCESCA FUSCO (Unità di personale interno)

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Variabilità del genoma ed alterazioni genetiche nell'uomo e loro impatto biologico - (SV.P13.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Gene (Rivista)

Editore di

• Elsevier (Editore)