Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion (Articolo in rivista)

Type
Label
  • Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.cmet.2011.03.015 (literal)
Alternative label
  • Wiederkehr, Andreas; Gergo Szanda; Akhmedov, Dmitry; Mataki, Chikage; Heizmann, Claus W.; Schoonjans, Kristina; Pozzan, Tullio; Spaet, Andras; Wollheim, Claes B. (2011)
    Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion
    in Cell metabolism
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Wiederkehr, Andreas; Gergo Szanda; Akhmedov, Dmitry; Mataki, Chikage; Heizmann, Claus W.; Schoonjans, Kristina; Pozzan, Tullio; Spaet, Andras; Wollheim, Claes B. (literal)
Pagina inizio
  • 601 (literal)
Pagina fine
  • 611 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/21531342 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 13 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 11 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • University of Geneva; University of Alberta; Semmelweis University; Ecole Polytechnique Federale de Lausanne; University of Zurich; CNR Institute of Neuroscience ; Venetian Inst Mol Med; Hungarian Academy of Sciences (literal)
Titolo
  • Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion (literal)
Abstract
  • Mitochondrial Ca2+ signals have been proposed to accelerate oxidative metabolism and ATP production to match Ca2+-activated energy-consuming processes. Efforts to understand the signaling role of mitochondrial Ca2+ have been hampered by the inability to manipulate matrix Ca2+ without directly altering cytosolic Ca2+. We were able to selectively buffer mitochondrial Ca2+ rises by targeting the Ca2+-binding protein SING to the matrix. We find that matrix Ca2+ controls signal-dependent NAD(P)H formation, respiration, and ATP changes in intact cells. Furthermore, we demonstrate that matrix Ca2+ increases are necessary for the amplification of sustained glucose-dependent insulin secretion in cells. Through the regulation of NAD(P)H in adrenal glomerulosa cells, matrix Ca2+ also acts as a positive signal in reductive biosynthesis, which stimulates aldosterone secretion. Our dissection of cytosolic and mitochondrial Ca2+ signals reveals the physiological importance of matrix Ca2+ in energy metabolism required for signal-dependent hormone secretion. (literal)
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