A new assessment tool for parkinson disease: The nigral lesion load obtained by transcranial sonography (Articolo in rivista)

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  • A new assessment tool for parkinson disease: The nigral lesion load obtained by transcranial sonography (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.7863/ultra.33.9.1635 (literal)
Alternative label
  • Sanzaro E.; Iemolo F.; Duro G.; Malferrari G. (2014)
    A new assessment tool for parkinson disease: The nigral lesion load obtained by transcranial sonography
    in Journal of ultrasound in medicine (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sanzaro E.; Iemolo F.; Duro G.; Malferrari G. (literal)
Pagina inizio
  • 1635 (literal)
Pagina fine
  • 1640 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84907195188&partnerID=q2rCbXpz (literal)
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  • 33 (literal)
Rivista
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  • 6 (literal)
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  • 9 (literal)
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  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
  • PubMed (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Neurology, Hospital of Vittoria, Ragusa, Italy; National Research Council, Institute of Biomedicine and Molecular Immunology, Palermo, Italy; Department of Neurology, Arcispedale S. Maria Nuova, Reggio Emilia, Italy (literal)
Titolo
  • A new assessment tool for parkinson disease: The nigral lesion load obtained by transcranial sonography (literal)
Abstract
  • Objectives: A sonographic method that provides for the measurement of a single frozen image and ignores the remaining portions of the midbrain has been used recently as a biological marker of Parkinson disease. We propose a new approach to evaluating the midbrain: obtaining the nigral lesion load, with which it is possible to acquire an estimate of the real damage to the substantia nigra.,Methods: We studied 60 patients with Parkinson disease and classified them according to the Hoehn and Yahr scale (Neurology 1967; 17: 427-442). Magnetic resonance imaging of the brain, ioflupane-labeled single-photon emission computed tomography, and technetium Tc 99m-labeled single-photon emission computed tomography were performed. Assessment of the midbrain parenchyma was performed with transcranial sonography to quantify the extent of hyperechoic signals on 2 different scans (upper and lower substantia nigra).,[object Object],Conclusions: Transcranial sonography is a useful tool for Parkinson disease workup. A single measurement of substantia nigra echogenicity may be insufficient for an optimal definition of the stage of the disease. A study of the entire midbrain may deliver more information than a single measurement. © 2014 by the American Institute of Ultrasound in Medicine. (literal)
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