5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.3389/fncel.2014.00250 (literal)

Alternative label

• Ciranna, Lucia; Catania, Maria Vincenza (2014)
  5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders
  in Frontiers in cellular neuroscience
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ciranna, Lucia; Catania, Maria Vincenza (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 8 (literal)

Rivista

• Frontiers in cellular neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 17 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Catania; Natl Res Council Italy CNR; IRCCS Oasi Maria SS (literal)

Titolo

• 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders (literal)

Abstract

• Serotonin type 7 receptors (5-HT7) are expressed in several brain areas, regulate brain development, synaptic transmission and plasticity, and therefore are involved in various brain functions such as learning and memory. A number of studies suggest that 5-HT7 receptors could be potential pharmacotherapeutic target for cognitive disorders. Several abnormalities of serotonergic system have been described in patients with autism spectrum disorder (ASD), including abnormal activity of 5-HT transporter, altered blood and brain 5-HT levels, reduced 5-HT synthesis and altered expression of 5-HT receptors in the brain. A specific role for 5-HT7 receptors in ASD has not yet been demonstrated but some evidence implicates their possible involvement. We have recently shown that 5-HT7 receptor activation rescues hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome, a monogenic cause of autism. Several other studies have shown that 5-HT7 receptors modulate behavioral flexibility, exploratory behavior, mood disorders and epilepsy, which include core and co-morbid symptoms of ASD. These findings further suggest an involvement of 5-HT7 receptors in ASD. Here, we review the physiological roles of 5-HT7 receptors and their implications in Fragile X Syndrome and other ASD. (literal)

Prodotto di

• Markers molecolari nelle malattie ereditarie e tumori del Sistema Nervoso (ME.P02.011.001) (Modulo)
• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• MARIA VINCENZA CATANIA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Markers molecolari nelle malattie ereditarie e tumori del Sistema Nervoso (ME.P02.011.001) (Modulo)

Autore CNR di

• MARIA VINCENZA CATANIA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Frontiers in cellular neuroscience (Rivista)

Insieme di parole chiave di

• Parole chiave di "5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders" (Insieme di parole chiave)