Otx genes and seizure susceptibility (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Otx genes and seizure susceptibility (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Alternative label

• Yuri Bozzi, Antonio Simeone* (2014)
  Otx genes and seizure susceptibility
  in Molecular & Cellular Epilepsy
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Yuri Bozzi, Antonio Simeone* (literal)

Rivista

• Molecular & Cellular Epilepsy (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Laboratory of Molecular Neuropathology, Centre for Integrative Biology, University of Trento, Italy 2Institute of Neuroscience, CNR, Pisa, Italy 3Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Naples, Italy 4IRCCS Neuromed, Pozzilli (Isernia), Italy (literal)

Titolo

• Otx genes and seizure susceptibility (literal)

Abstract

• Homeobox-containing transcription factors crucially regulate the patterning and regionalization of the developing nervous system, as well as the proliferation, survival and differentiation of distinct neuronal populations. Altered expression of these factors markedly impacts the structure and function of the embryonic and adult central nervous system (CNS). In both humans and mice, mutations of homeobox genes have been associated to severe syndromes characterized by developmental CNS defects, which often lead to the occurrence of seizures in the adult life. Among homeobox genes, Otx genes (Otx1 and Otx2) are crucially involved in brain regionalization. Our previous work showed that mice lacking Otx1 present cerebral cortex defects and develop epilepsy, whereas mice with conditional deletion or overexpression of Otx2 show profound alterations in midbrain-to-forebrain circuits, which are accompanied by an abnormal response to experimentally-induced seizures. In this brief review, we highlight and discuss the major findings suppporting the role of Otx genes in sculpting midbrain and forebrain circuits involved in epileptogenesis. (literal)

Prodotto di

• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)
• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• ANTONIO SIMEONE (Persona)

Incoming links:

Prodotto

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)

Autore CNR di

• ANTONIO SIMEONE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular & Cellular Epilepsy (Rivista)