Zn2+'s Ability to Alter the Distribution of Cu2+ among the Available Binding Sites of A beta(1-16)-Polyethylenglycol-ylated Peptide: Implications in Alzheimer's Disease (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Zn2+'s Ability to Alter the Distribution of Cu2+ among the Available Binding Sites of A beta(1-16)-Polyethylenglycol-ylated Peptide: Implications in Alzheimer's Disease (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/ic101537m (literal)

Alternative label

• Damante, Chiara A.; Oesz, Katalin; Nagy, Zoltan; Grasso, Giuseppe; Pappalardo, Giuseppe; Rizzarelli, Enrico; Sovago, Imre (2011)
  Zn2+'s Ability to Alter the Distribution of Cu2+ among the Available Binding Sites of A beta(1-16)-Polyethylenglycol-ylated Peptide: Implications in Alzheimer's Disease
  in Inorganic chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Damante, Chiara A.; Oesz, Katalin; Nagy, Zoltan; Grasso, Giuseppe; Pappalardo, Giuseppe; Rizzarelli, Enrico; Sovago, Imre (literal)

Pagina inizio

• 5342 (literal)

Pagina fine

• 5350 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 50 (literal)

Rivista

• Inorganic chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 12 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Catania; University of Debrecen; University of Debrecen; Consiglio Nazionale delle Ricerche (CNR) (literal)

Titolo

• Zn2+'s Ability to Alter the Distribution of Cu2+ among the Available Binding Sites of A beta(1-16)-Polyethylenglycol-ylated Peptide: Implications in Alzheimer's Disease (literal)

Abstract

• The formation of mixed copper(II) and zinc(II) complexes with A beta(1-16)-PEG has been investigated. The peptide fragment forms stable mixed metal complexes at physiological pH in which the His13/His14 dyad is the zinc(II)'s preferred binding site, while copper(II) coordination occurs at the N-terminus also involving the His6 imidazole. Copper(II) is prevented by zinc(II) excess from the binding to the two His residues, His13 and His14. As the latter binding mode has been recently invoked to explain the redox activity of the copper-A beta complex, the formation of ternary metal complexes may justify the recently pro:Dosed protective role of zinc(II) in Alzheimer's disease. Therefore, the reported results suggest that zinc(II) competes with copper for A beta binding and inhibits copper-mediated A beta redox chemistry. (literal)

Prodotto di

• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• GIUSEPPE PAPPALARDO (Unità di personale interno)
• ENRICO RIZZARELLI (Unità di personale esterno)

Incoming links:

Autore CNR di

• GIUSEPPE PAPPALARDO (Unità di personale interno)
• ENRICO RIZZARELLI (Unità di personale esterno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Inorganic chemistry (Rivista)