The heritability of beta cell function parameters in a mixed meal test design (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The heritability of beta cell function parameters in a mixed meal test design (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00125-011-2060-5 (literal)

Alternative label

• Simonis-Bik, A.M.;Boomsma, D.I.;Dekker, J.M.;Diamant, M.;de Geus, E.J.;t Hart, L.M.;Heine, R.J.;Kramer, M.H.;Maassen, J.A.;Mari, A.;Tura, A.;Willemsen, G.;Eekhoff, E.M. (2011)
  The heritability of beta cell function parameters in a mixed meal test design
  in Diabetologia (Berl.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Simonis-Bik, A.M.;Boomsma, D.I.;Dekker, J.M.;Diamant, M.;de Geus, E.J.;t Hart, L.M.;Heine, R.J.;Kramer, M.H.;Maassen, J.A.;Mari, A.;Tura, A.;Willemsen, G.;Eekhoff, E.M. (literal)

Pagina inizio

• 1043 (literal)

Pagina fine

• 1051 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/21311857 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 54 (literal)

Rivista

• Diabetologia (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WoS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1, 4, 7, 9: Diabetes Center, VU University Medical Center, ZH 4A62, PO Box 7057, 1007 MB Amsterdam, the Netherlands; 2, 5, 12: Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands; 3: Epidemiology and Biostatistics and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; 6: Molecular Cell Biology and Section Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; 8: Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands; 10, 11: CNR Institute of Biomedical Engineering, Padova, Italy; (literal)

Titolo

• The heritability of beta cell function parameters in a mixed meal test design (literal)

Abstract

• A total of 183 healthy participants (77 men), recruited from the Netherlands Twin Register, took part in a 4 h protocol, which included a mixed meal test. Participants were Dutch twin pairs and their siblings, aged 20 to 49 years. All members within a family were of the same sex. Insulin sensitivity, insulinogenic index, insulin response and postprandial glycaemia were assessed, as well as model-derived parameters of beta cell function, in particular beta cell glucose sensitivity and insulin secretion rates. Genetic modelling provided the heritability of all traits. Multivariate genetic analyses were performed to test for overlap in the genetic factors influencing beta cell function, waist circumference and insulin sensitivity. (literal)
• Aims/hypothesis: We estimated the heritability of individual differences in beta cell function after a mixed meal test designed to assess a wide range of classical and model-derived beta cell function parameters. Methods: A total of 183 healthy participants (77 men), recruited from the Netherlands Twin Register, took part in a 4 h protocol, which included a mixed meal test. Participants were Dutch twin pairs and their siblings, aged 20 to 49 years. All members within a family were of the same sex. Insulin sensitivity, insulinogenic index, insulin response and postprandial glycaemia were assessed, as well as model-derived parameters of beta cell function, in particular beta cell glucose sensitivity and insulin secretion rates. Genetic modelling provided the heritability of all traits. Multivariate genetic analyses were performed to test for overlap in the genetic factors influencing beta cell function, waist circumference and insulin sensitivity. Results: Significant heritabilities were found for insulinogenic index (63%), beta cell glucose sensitivity (50%), insulin secretion during the first 2 h postprandial (42-47%) and postprandial glycaemia (43-52%). Genetic factors influencing beta cell glucose sensitivity and insulin secretion during the first 30 postprandial min showed only negligible overlap with the genetic factors that influence waist circumference and insulin sensitivity. Conclusions/interpretation: The highest heritability for postprandial beta cell function was found for the insulinogenic index, but the most specific indices of heritability of beta cell function appeared to be beta cell glucose sensitivity and the insulin secretion rate during the first 30 min after a mixed meal. © The Author(s) 2011. (literal)

Prodotto di

• Institute of biomedical engineering (ISIB) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• ANDREA TURA (Unità di personale interno)
• ANDREA MARI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "The heritability of beta cell function parameters in a mixed meal test design" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• ANDREA MARI (Unità di personale interno)
• ANDREA TURA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetologia (Rivista)

Insieme di parole chiave di

• Parole chiave di "The heritability of beta cell function parameters in a mixed meal test design" (Insieme di parole chiave)