Non-esterified fatty acid dynamics during oral glucose tolerance test in women with former gestational diabetes (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Non-esterified fatty acid dynamics during oral glucose tolerance test in women with former gestational diabetes (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1464-5491.2011.03477.x (literal)

Alternative label

• Tura, A.; Pacini, G.; Winhofer, Y.; Bozkurt, L.; Di Benedetto, G.; Morbiducci, U.; Roden, M.; Kautzky-Willer, A. (2011)
  Non-esterified fatty acid dynamics during oral glucose tolerance test in women with former gestational diabetes
  in Diabetic medicine
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Tura, A.; Pacini, G.; Winhofer, Y.; Bozkurt, L.; Di Benedetto, G.; Morbiducci, U.; Roden, M.; Kautzky-Willer, A. (literal)

Pagina inizio

• 351 (literal)

Pagina fine

• 358 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/21988496 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 29 (literal)

Rivista

• Diabetic medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• epub (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1, 2: Metabolic Unit, Institute of Biomedical Engineering (ISIB-CNR), Padua, Italy; 3, 4, 8: Clinic of Internal Medicine III, Medical University of Vienna, Austria; 5, 6: Departmentof Mechanics, Politecnico di Torino, Turin, Italy,; 7: Department of Metabolic Diseases, Heinrich-Heine University, Dusseldorf / Institute for Clinical Diabetology,German Diabetes Center, Dusseldorf, Germany / Karl-Landsteiner Institute for Endocrinology and Metabolism, Vienna, Austria (literal)

Titolo

• Non-esterified fatty acid dynamics during oral glucose tolerance test in women with former gestational diabetes (literal)

Abstract

• Aims Women with former gestational diabetes are at increased risk of Type 2 diabetes, which likely relates to hyperlipidaemia and ectopic lipid storage, mainly in the liver. Here, we examined the response of non-esterified fatty acid dynamics to oral glucose loading (oral glucose tolerance test). Methods We studied women with former gestational diabetes with normal glucose tolerance (n = 60) or impaired glucose metabolism (n = 12) and compared them with healthy women after normal pregnancy (control subjects, n = 15). During a 3-h oral glucose tolerance test, glucose, insulin and non-esterified fatty acid were frequently measured to compute the area under the non-esterified fatty acid curve and parameters of beta-cell function and insulin sensitivity. Through mathematical modelling, we assessed insulin sensitivity of lipolysis inhibition and the fractional non-esterified fatty acid turnover rate. We also measured some serum liver enzymes. Results Women with former gestational diabetes were slightly older and had greater body mass than control subjects. Subjects with impaired glucose metabolism had lower oral glucose insulin sensitivity, but higher fasting insulin and area under the non-esterified fatty acid curve, which inversely related to oral glucose insulin sensitivity and independently determined mean glycaemia. Model-derived non-esterified fatty acid parameters were lower in subjects with impaired glucose metabolism than in control subjects, particularly sensitivity of non-esterified fatty acid inhibition to insulin (2.50 +/- 0.52 vs. 1.06 +/- 0.20.10-2 ml/mu U). Also, subjects with impaired glucose metabolism had higher liver transaminases. However, all non-esterified fatty acid parameters showed only modest inverse correlation with liver transaminases. Conclusions Despite greater insulinaemia, circulating non-esterified fatty acids are higher in women with former gestational diabetes than in control subjects, which likely results from reduced sensitivity of lipolysis inhibition to insulin. This parameter may serve as indicator of an early metabolic derangement in this population at risk for diabetes. (literal)

Prodotto di

• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• ANDREA TURA (Unità di personale interno)
• GIOVANNI PACINI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Non-esterified fatty acid dynamics during oral glucose tolerance test in women with former gestational diabetes" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• GIOVANNI PACINI (Unità di personale interno)
• ANDREA TURA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetic medicine (Rivista)

Insieme di parole chiave di

• Keywords of "Non-esterified fatty acid dynamics during oral glucose tolerance test in women with former gestational diabetes" (Insieme di parole chiave)