Postprandial metabolic responses to mixed versus liquid meal tests in healthy men and men with type 2 diabetes (Articolo in rivista)

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  • Postprandial metabolic responses to mixed versus liquid meal tests in healthy men and men with type 2 diabetes (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Brodovicz, K.G.;Girman, C.J.;Simonis-Bik, A.M.;Rijkelijkhuizen, J.M.;Zelis, M.;Bunck, M.C.;Mari, A.;Nijpels, G.;Eekhoff, E.M.;Dekker, J.M. (2011)
    Postprandial metabolic responses to mixed versus liquid meal tests in healthy men and men with type 2 diabetes
    in Diabetes research and clinical practice (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Brodovicz, K.G.;Girman, C.J.;Simonis-Bik, A.M.;Rijkelijkhuizen, J.M.;Zelis, M.;Bunck, M.C.;Mari, A.;Nijpels, G.;Eekhoff, E.M.;Dekker, J.M. (literal)
Pagina inizio
  • 449 (literal)
Pagina fine
  • 455 (literal)
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  • http://www.ncbi.nlm.nih.gov/pubmed/21955958 (literal)
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  • 94 (literal)
Rivista
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  • 3 (literal)
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  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
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  • 1, 2: Department of Epidemiology, Merck Research Laboratories, Merck, UG1D60, 351 N Sumneytown Pike, North Wales, PA 19454, USA; 3, 5, 6, 9: Department of Internal Medicine, Section of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands; 4: EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands; 7: Institute of Biomedical Engineering, National Research Council, Padua, Italy; 8: EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands / Department of General Practice, VU University Medical Center, Amsterdam, The Netherlands; 10: EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands / Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands (literal)
Titolo
  • Postprandial metabolic responses to mixed versus liquid meal tests in healthy men and men with type 2 diabetes (literal)
Abstract
  • AIMS: Compare metabolic responses after mixed versus liquid meals of similar caloric/nutritional content in healthy and type 2 diabetes (T2D) subjects. METHODS: Ten healthy men and 10 men with T2D received mixed and liquid meals after an overnight fast. Classical (insulinogenic index; insulin/glucose areas under curves, AUC(insulin)/AUC(glucose)) and model-based (beta-cell glucose sensitivity; rate sensitivity; potentiation factor ratio, PFR) beta-cell function estimates were calculated. Between-meal differences in glucose, insulin, C-peptide, triglyceride (TG), beta-cell function and oral glucose insulin sensitivity (OGIS) and between-meal correlations for beta-cell function and OGIS were evaluated. RESULTS: Among healthy subjects, beta-cell function and OGIS were similar between meals. C-peptide (p=0.03), insulin (p=0.002), AUC(insulin)/AUC(glucose) (p=0.004) and insulin secretion (p=0.04) were higher after the liquid meal. Among T2D subjects, glucose, insulin, C-peptide, beta-cell function, and OGIS were similar. PFR was higher (p=0.004) and TG increased more slowly (p=0.002) after the liquid meal. OGIS and beta-cell function were correlated during both meals in both groups (r=0.66-0.98), except incremental AUC(insulin)/AUC(glucose), rate sensitivity, and, in healthy subjects, PFR. CONCLUSIONS: Metabolic responses after mixed or liquid meals of similar content were highly correlated in T2D and healthy subjects. In T2D, the liquid meal produced beta-cell function estimates generally similar to the mixed meal. (literal)
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