Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients (Articolo in rivista)

Type
Label
  • Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1530/EJE-10-1003 (literal)
Alternative label
  • Battezzati, A., Mari, A., Zazzeron, L., Alicandro, G., Claut, L., Battezzati, P.M., Colombo, C. (2011)
    Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients
    in European journal of endocrinology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Battezzati, A., Mari, A., Zazzeron, L., Alicandro, G., Claut, L., Battezzati, P.M., Colombo, C. (literal)
Pagina inizio
  • 69 (literal)
Pagina fine
  • 76 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/21502328 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 165 (literal)
Rivista
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1: International Center for the Assessment of Nutritional Status - DiSTAM, Università degli Studi di Milano, Via Botticelli, 21, 20133 Milan, Italy /CF Center, Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy; 2: C.N.R. Institute of Biomedical Engineering, 35127 Padua, Italy; 3, 4, 5, 7: CF Center, Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy; 6: Division of Internal Medicine, San Paolo Hospital, University of Milan, 20142 Milan, Italy (literal)
Titolo
  • Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients (literal)
Abstract
  • BACKGROUND: Cystic fibrosis (CF)-related diabetes is a leading complication of CF and is associated with pulmonary and nutritional deterioration, years before an evident hyperglycemia, possibly because of insulin deficiency and resistance. AIM: To evaluate glucose tolerance, insulin secretion, and insulin sensitivity by a widely applicable method suitable for accurate and prospective measurements in a CF population. METHODS: A total of 165 CF subjects (80 females) aged 17+/-5 years and 18 age- and sex-matched healthy controls (CON) received an oral glucose tolerance test with glucose, insulin and C-peptide determinations. Insulin sensitivity was defined on the basis of glucose and insulin concentrations using the oral glucose insulin sensitivity index, whereas beta-cell function was determined on the basis of a model relating insulin secretion (C-peptide profile) to glucose concentration. RESULTS: Fifteen percent of CF patients had glucose intolerance and 6% had diabetes without fasting hyperglycemia and 3% had diabetes with fasting hyperglycemia. beta-cell function was reduced in CF patients compared with CON (70.0+/-4.1 vs 117.9+/-11.6 pmol/min per m(2) per mM, P<0.001) and decreased significantly with age by -2.7 pmol/min per m(2) per mM per year (confidence interval (CI) -4.5 to -0.82), i.e. almost 4% yearly. The early insulin secretion index was also reduced. Insulin sensitivity was similar to CON. CF patients who attained glucose tolerance comparable to CON had lower beta-cell function and higher insulin sensitivity. CONCLUSION: The major alteration in insulin secretion and insulin sensitivity of CF patients is slowly declining beta-cell function, consisting of delayed and reduced responsiveness to hyperglycemia, that in CF patients with normal glucose tolerance may be compensated by an increased insulin sensitivity. (literal)
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