Chronic TNF-alpha Neutralization Does Not Improve Insulin Resistance or Endothelial Function in \"Healthy\" Men with Metabolic Syndrome (Articolo in rivista)

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Label
  • Chronic TNF-alpha Neutralization Does Not Improve Insulin Resistance or Endothelial Function in \"Healthy\" Men with Metabolic Syndrome (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.2119/molmed.2010.00221 (literal)
Alternative label
  • Wascher, T.C.;Lindeman, J.H.;Sourij, H.;Kooistra, T.;Pacini, G.;Roden, M., (2011)
    Chronic TNF-alpha Neutralization Does Not Improve Insulin Resistance or Endothelial Function in "Healthy" Men with Metabolic Syndrome
    in Molecular medicine (Camb. Mass., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Wascher, T.C.;Lindeman, J.H.;Sourij, H.;Kooistra, T.;Pacini, G.;Roden, M., (literal)
Pagina inizio
  • 189 (literal)
Pagina fine
  • 193 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/21103669 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 17 (literal)
Rivista
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  • 5 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3-4 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1: Metabolism and Vascular Biology Research Group, Department of Internal Medicine, Medical University of Graz, Graz, Austria / First Department of Medicine, Hanuschkrankenhaus, Vienna, Austria; 2: Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands; 3: Metabolism and Vascular Biology Research Group, Department of Internal Medicine, Medical University of Graz, Graz, Austria ; Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria; 4: TNO Quality of Life, Leiden, The Netherlands; 5: Metabolic Unit, Institute of Biomedical Engineering, Italian National Research Council, Padova, Italy; 6: First Department of Medicine, Hanuschkrankenhaus, Vienna, Austria / Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Department of Medicine/Metabolic Disease, Heinrich-Heine University, Düsseldorf, Germany (literal)
Titolo
  • Chronic TNF-alpha Neutralization Does Not Improve Insulin Resistance or Endothelial Function in \"Healthy\" Men with Metabolic Syndrome (literal)
Abstract
  • The possible contribution of tumor necrosis factor-alpha (TNF-alpha) to the development of obesity-associated insulin resistance in humans is still controversial. Our study investigated the effect of TNF-alpha neutralization on insulin resistance in healthy, obese and insulin resistant men. We performed a prospective, randomized, double-blind placebo-controlled trial in nine young, healthy obese male subjects with metabolic syndrome and insulin resistance. Volunteers received three infusions (wks 0, 2 and 6) of infliximab or placebo. Insulin resistance was measured at baseline and after 70 d by homeostatic model assessment (HOMA) index as well as by minimal model analysis of an intravenous glucose tolerance test. Endothelial function was accessed before and after intervention by flow mediated dilation. Infliximab improved the inflammatory status as indicated by reduced high sensitivity C-reactive protein (hsCRP) and fibrinogen levels (2.77 +/- 0.6 to 1.8 +/- 0.5 mu g/L, and 3.42 +/- 0.18 to 3.18 +/- 0.28 g/L; (day 0 and day 70, P = 0.020 and 0.037 respectively), but did not improve insulin resistance (HOMA index and intravenous glucose-tolerance test [ivGGT]) or endothelial function. Despite improvements in inflammatory status, chronic TNF-alpha neutralization does not improve insulin resistance or endothelial function in seemingly healthy, but obese, insulin-resistant volunteers. This study severely questions the proposal that TNF-alpha is a causative link between adiposity and insulin resistance. (C) 2011 The Feinstein Institute for Medical Research, www.feinsteininstitute.org Online address: http://www.molmed.org doi: 10.2119/molmed.2010.00221 (literal)
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