http://www.cnr.it/ontology/cnr/individuo/prodotto/ID30437

Mechanism and Effects of Glucose Absorption during an Oral Glucose Tolerance Test Among Females and Males (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Mechanism and Effects of Glucose Absorption during an Oral Glucose Tolerance Test Among Females and Males (Articolo in rivista) (literal)

Anno

2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1210/jc.2010-1398 (literal)

Alternative label

Anderwald, C.;Gastaldelli, A.;Tura, A.;Krebs, M.;Promintzer-Schifferl, M.;Kautzky-Willer, A.;Stadler, M.;DeFronzo, R.A.;Pacini, G.;Bischof, M.G. (2011)
Mechanism and Effects of Glucose Absorption during an Oral Glucose Tolerance Test Among Females and Males
in The Journal of clinical endocrinology and metabolism; Endocrine Society, Chevy Chase (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Anderwald, C.;Gastaldelli, A.;Tura, A.;Krebs, M.;Promintzer-Schifferl, M.;Kautzky-Willer, A.;Stadler, M.;DeFronzo, R.A.;Pacini, G.;Bischof, M.G. (literal)

Pagina inizio

515 (literal)

Pagina fine

524 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.ncbi.nlm.nih.gov/pubmed/21147888 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

96 (literal)

Rivista

?The ?Journal of clinical endocrinology and metabolism (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

2 (literal)

Note

ISI Web of Science (WOS) (literal)

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[ 1,4,5,6,10 ] Med Univ Vienna, Dept Internal Med 3, Div Endocrinol & Metab, A-1090 Vienna, Austria [ 1,3,9 ] CNR, Inst Biomed Engn, Metab Unit, I-35127 Padua, Italy [ 2] CNR, Inst Clin Physiol, I-56124 Pisa, Italy [ 7 ] Hietzing Hosp, Med Dept Metab Dis & Nephrol 3, A-1130 Vienna, Austria [ 7 ] Hietzing Hosp, Karl Landsteiner Inst Metab Dis & Nephrol, A-1130 Vienna, Austria [ 8 ] Univ Texas Hlth Sci Ctr San Antonio, Dept Med Diabet, San Antonio, TX 78207 USA [ 7 ] St Elizabeth Hosp, Med Direct, A-1030 Vienna, Austria (literal)

Titolo

Mechanism and Effects of Glucose Absorption during an Oral Glucose Tolerance Test Among Females and Males (literal)

Abstract

Background: Several epidemiological studies revealed sex-specific differences during oral glucose tolerance tests (OGTTs), such as higher prevalence of glucose intolerance (i.e. increased glucose at the end of the OGTT) in females, which was not yet explained. Thus, we aimed to analyze sex-related distinctions on OGTT glucose metabolism, including gut absorption, in healthy humans. Methods: Females (n = 48) and males (n = 26) with comparable age (females, 45 +/- 1 yr; males, 44 +/- 2 yr) and body mass index (both, 25 +/- 1 kg/m(2)) but different height (females, 166 +/- 1 cm; males, 180 +/- 2 cm; P < 0.000001), all normally glucose tolerant, as tested by frequently sampled, 3-h (75-g) OGTTs, underwent hyperinsulinemic [40 mU/(min . m(2))] isoglycemic clamp tests with simultaneous measurement of endogenous glucose (D-[6,6-(2)H(2)] glucose) production (EGP). EGP and glucose disappearance during OGTT were calculated from logarithmic relationships with clamp test insulin concentrations. After reliable model validation by double-tracer technique (r = 0.732; P < 0.007), we calculated and modeled gut glucose absorption (ABS). Results: Females showed lower (P < 0.05) fasting EGP [1.4 +/- 0.1 mg/(kg . min)] than males [1.7 +/- 0.1 mg/(kg . min)] but comparable whole-body insulin sensitivity in clamp tests [females, 8.1 +/- 0.4 mg/(kg . min); males, 8.3 +/- 0.6 mg/(kg . min)]. Plasma glucose OGTT concentrations were higher (P < 0.04) from 30-40 min in males but from 120-180 min in females. Glucose absorption rates were 21-46% increased in the initial 40 min in males but in females by 27-40% in the third hour (P < 0.05). Gut glucose half-life was markedly higher in females (79 +/- 2 min) than in males (65 +/- 3 min, P < 0.0001) and negatively related to body height (r = -0.481; P < 0.0001). Conclusions: This study in healthy, glucose-tolerant humans shows for the first time different ABS rates during OGTT in women and men and a negative relationship between body height and gut glucose half-life. Prolonged ABS in females might therefore contribute to higher plasma glucose concentrations at the end of OGTT. (J Clin Endocrinol Metab 96: 515-524, 2011) (literal)

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