Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs (Articolo in rivista)

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  • Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1172/JCI45472 (literal)
Alternative label
  • Ramnanan, C.J.;Saraswathi, V.;Smith, M.S.;Donahue, E.P.;Farmer, B.;Farmer, T.D.;Neal, D.;Williams, P.E.;Lautz, M.;Mari, A.;Cherrington, A.D.;Edgerton, D.S., (2011)
    Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
    in The Journal of clinical investigation
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ramnanan, C.J.;Saraswathi, V.;Smith, M.S.;Donahue, E.P.;Farmer, B.;Farmer, T.D.;Neal, D.;Williams, P.E.;Lautz, M.;Mari, A.;Cherrington, A.D.;Edgerton, D.S., (literal)
Pagina inizio
  • 3713 (literal)
Pagina fine
  • 3723 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/21865644 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 121 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 11 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 9 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1-7, 9, 11-12: Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; 8: Division of Surgical Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; 10: Institute of Biomedical Engineering, National Research Council, Padova, Italy (literal)
Titolo
  • Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs (literal)
Abstract
  • In rodents, acute brain insulin action reduces blood glucose levels by suppressing the expression of enzymes in the hepatic gluconeogenic pathway, thereby reducing gluconeogenesis and endogenous glucose production (EGP). Whether a similar mechanism is functional in large animals, including humans, is unknown. Here, we demonstrated that in canines, physiologic brain hyperinsulinemia brought about by infusion of insulin into the head arteries (during a pancreatic clamp to maintain basal hepatic insulin and glucagon levels) activated hypothalamic Akt, altered STAT3 signaling in the liver, and suppressed hepatic gluconeogenic gene expression without altering EGP or gluconeogenesis. Rather, brain hyperinsulinemia slowly caused a modest reduction in net hepatic glucose output (NHGO) that was attributable to increased net hepatic glucose uptake and glycogen synthesis. This was associated with decreased levels of glycogen synthase kinase 3 beta (GSK3 beta) protein and mRNA and with decreased glycogen synthase phosphorylation, changes that were blocked by hypothalamic PI3K inhibition. Therefore, we conclude that the canine brain senses physiologic elevations in plasma insulin, and that this in turn regulates genetic events in the liver. In the context of basal insulin and glucagon levels at the liver, this input augments hepatic glucose uptake and glycogen synthesis, reducing NHGO without altering EGP. (literal)
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