Enantiomeric separation of new cathinone derivatives designer drugs by capillary electrochromatography using a chiral stationary phase, based on amylose tris(5-chloro-2-methylphenylcarbamate) (Articolo in rivista)

Type
Label
  • Enantiomeric separation of new cathinone derivatives designer drugs by capillary electrochromatography using a chiral stationary phase, based on amylose tris(5-chloro-2-methylphenylcarbamate) (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/elps.201400085 (literal)
Alternative label
  • Z. Aturki, M.G. Schmid, B. Chankvetadze, S. Fanali (2014)
    Enantiomeric separation of new cathinone derivatives designer drugs by capillary electrochromatography using a chiral stationary phase, based on amylose tris(5-chloro-2-methylphenylcarbamate)
    in Electrophoresis (Weinh., Internet)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Z. Aturki, M.G. Schmid, B. Chankvetadze, S. Fanali (literal)
Pagina inizio
  • 3242 (literal)
Pagina fine
  • 3249 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84917692556&partnerID=q2rCbXpz (literal)
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  • 35 (literal)
Rivista
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  • 21-22 (literal)
Note
  • Scopu (literal)
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  • Istituto di Metodologie Chimiche (IMC), Consiglio Nazionale delle Ricerche, Roma, Italia Institute of Pharmaceutical Sciences, Karl-Franzens-University Graz, Graz, Austria Institute of Physical and Analytical Chemistry, Tbilisi State University, Tbilisi, Georgia (literal)
Titolo
  • Enantiomeric separation of new cathinone derivatives designer drugs by capillary electrochromatography using a chiral stationary phase, based on amylose tris(5-chloro-2-methylphenylcarbamate) (literal)
Abstract
  • In this study, a chiral CECmethod for the enantiomeric separation of ten cathinone derivatives, bymeans of a polysaccharide-based chiral stationary phase, has been developed. Capillary columns of 100 ?m id packed with amylose tris(5-chloro-2-methylphenylcarbamate) coated on silica, also called Sepapak 3 or Lux Amylose-2, were used to achieve the enantioseparation of the studied designer drugs. Enantioresolution, chromatographic retention, and separation efficiency were evaluated in dependence of mobile-phase composition in terms of the content of the organicmodifier, nature, and pH buffer. To obtain a sensitivity improvement, a field-amplified sample injection was evaluated optimizing the sample solvent composition and injection time. The LODs and LOQs values were in the range 25-100 and 50-150 ng/mL, respectively, for all the racemic compounds. Good results in terms of resolution (Rs), separation efficiency (N/m), and short analysis times were obtained using a mixture of ACN/methanol/sodium acetate pH 9 (89/10/1, v/v/v). Applying a voltage of 10 kV and a temperature of 20°C, the analyzed cathinone derivatives were separated in their enantiomers in less than 10min. A study, concerning the method precision, in terms of intra- and interday repeatability and column-to-column reproducibility was carried out in accordance with the analytical procedures for method validation. Intra- and interday repeatability provided RSD values in the ranges 1.1-1.7, 1.3-2.3% for retention time and 1.3-2.6, 2.1-3.4% for peak area, respectively. (literal)
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