Systems biology of apoptosis and survival: Implications for drug development (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Systems biology of apoptosis and survival: Implications for drug development (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2174/138161211795049688 (literal)

Alternative label

• Pezzino, Salvatore; Paratore, Sabrina; Cavallaro, Sebastiano (2011)
  Systems biology of apoptosis and survival: Implications for drug development
  in Current pharmaceutical design (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pezzino, Salvatore; Paratore, Sabrina; Cavallaro, Sebastiano (literal)

Pagina inizio

• 190 (literal)

Pagina fine

• 203 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/record/display.url?eid=2-s2.0-79958184426&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 17 (literal)

Rivista

• Current pharmaceutical design (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 14 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Universita degli Studi di Catania; Consiglio Nazionale delle Ricerche (literal)

Titolo

• Systems biology of apoptosis and survival: Implications for drug development (literal)

Abstract

• The advent of \"systems biology\" has highlighted that any function of a biological system is rarely attributable to a single molecule or a single process. Hence, complex processes, such as apoptosis and survival, depend on the activity of an integrated network of genes and their encoded proteins, which almost never work alone but interact with each other in highly structured and incredibly complex ways. With the completion of genome sequencing in humans and model organisms, and the advent of DNA microarray technology, the transcriptional cascades and gene networks regulating neuronal apoptosis and survival are being elucidated providing new potential pharmacological targets. The emerging challenge is the effective selection of the myriad of targets to identify those with the most therapeutic utility. The present review will illustrate how the identification, prioritization and validation of preclinical therapeutics can be achieved through genomic analysis of critical pathways and networks in neuronal apoptosis and survival. © 2011 Bentham Science Publishers Ltd. (literal)

Prodotto di

• Genomica funzionale delle malattie ereditarie del sistema nervoso (ME.P05.010.001) (Modulo)
• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• SABRINA PARATORE (Persona)
• SEBASTIANO CAVALLARO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Systems biology of apoptosis and survival: Implications for drug development" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• SEBASTIANO CAVALLARO (Unità di personale interno)
• SABRINA PARATORE (Persona)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Genomica funzionale delle malattie ereditarie del sistema nervoso (ME.P05.010.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current pharmaceutical design (Rivista)

Insieme di parole chiave di

• Parole chiave di "Systems biology of apoptosis and survival: Implications for drug development" (Insieme di parole chiave)