In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.3109/17435390.2013.831500 (literal)

Alternative label

• Ucciferri, Nadia; Collnot, Eva-Marie; Gaiser, Birgit K.; Tirella, Annalisa; Stone, Vicki; Domenici, Claudio; Lehr, Claus-Michael; Ahluwalia, Arti (2014)
  In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response
  in Nanotoxicology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ucciferri, Nadia; Collnot, Eva-Marie; Gaiser, Birgit K.; Tirella, Annalisa; Stone, Vicki; Domenici, Claudio; Lehr, Claus-Michael; Ahluwalia, Arti (literal)

Pagina inizio

• 697 (literal)

Pagina fine

• 708 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://informahealthcare.com/doi/abs/10.3109/17435390.2013.831500 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 8 (literal)

Rivista

• Nanotoxicology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Pisa; Consiglio Nazionale delle Ricerche (CNR); Helmholtz Center Infectious Research; Heriot Watt University (literal)

Titolo

• In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response (literal)

Abstract

• After passage through biological barriers, nanomaterials inevitably end up in contact with the vascular endothelium and can induce cardiovascular damage. In this study the toxicity and sub-lethal effects of six types of nanoparticle, including four of industrial and biomedical importance, on human endothelial cells were investigated using different in vitro assays. The results show that all the particles investigated induce some level of damage to the cells and that silver particles were most toxic, followed by titanium dioxide. Furthermore, endothelial cells were shown to be more susceptible when exposed to silver nanoparticles under flow conditions in a bioreactor. The study underlines that although simple in vitro tests are useful to screen compounds and to identify the type of effect induced on cells, they may not be sufficient to define safe exposure limits. Therefore, once initial toxicity screening has been conducted on nanomaterials, it is necessary to develop more physiologically relevant in vitro models to better understand how nanomaterials can impact on human health. (literal)

Prodotto di

• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• CLAUDIO DOMENICI (Unità di personale interno)
• Nadia Ucciferri (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR di

• CLAUDIO DOMENICI (Unità di personale interno)
• Nadia Ucciferri (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nanotoxicology (Rivista)

Insieme di parole chiave di

• Keywords of "In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response" (Insieme di parole chiave)