A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.nbd.2011.01.013 (literal)

Alternative label

• D'Antoni S.; Berretta A.; Seminara G.; Longone P.; Giuffrida-Stella A.M.; Battaglia G.; Sortino M.A.; Nicoletti F.; Catania M.V. (2011)
  A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death
  in Neurobiology of disease
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D'Antoni S.; Berretta A.; Seminara G.; Longone P.; Giuffrida-Stella A.M.; Battaglia G.; Sortino M.A.; Nicoletti F.; Catania M.V. (literal)

Pagina inizio

• 252 (literal)

Pagina fine

• 264 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-79954628862&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 42 (literal)

Rivista

• Neurobiology of disease (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Neurological Sciences, National Research Council (ISN-CNR), via P. Gaifami 18, 95126 Catania, Italy; Department of Chemical Sciences, Section of Biochemistry, University of Catania, vl Andrea Doria 6, 95125 Catania, Italy; Unit of Molecular Neurobiology Santa Lucia Foundation, via del Fosso di Fiorano 64, 00143 Rome, Italy; IRCCS Neuromed, Località Camerelle, 86077 Pozzilli (IS), Italy; Department of Pharmacological Sciences, University of Catania, vl Andrea Doria 6, 95125 Catania, Italy; IRCCS Oasi Maria SS, via Conte Ruggero 73, 94018 Troina (EN), Italy (literal)

Titolo

• A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death (literal)

Abstract

• The causes of amyotrophic lateral sclerosis (ALS) are mostly undefined; however, excitotoxic injury and astrogliosis may contribute to motor neuron (MN) degeneration. Group I metabotropic glutamate (mGlu) receptors are over-expressed in reactive astrocytes in ALS, but the functional significance of this over-expression is presently unknown. We examined the role of group I mGlu receptors on excitotoxic death of spinal cord MNs grown in cultures enriched of astrocytes bearing a reactive phenotype. A prolonged exposure to the selective non-competitive mGlu5 receptor antagonist MPEP reduced AMPA-mediated toxicity and cobalt uptake in MNs. Expression levels of the GluR1 (but not GluR2) AMPA receptor subunit and levels of brain-derived neurotrophic factor (BDNF) were reduced in mixed spinal cord cultures pretreated with MPEP. In addition, neuroprotection by MPEP was less than additive with that produced by a neutralizing anti-BDNF antibody and a treatment with exogenous BDNF masked the protective effect of MPEP, suggesting that mGlu5 receptors and BDNF converge in facilitating excitotoxic MN death. The protective effect of MPEP was absent in cultures with a reduced number of astrocytes. We suggest that blocking astrocytic mGlu5 receptors is a potential therapeutic strategy in ALS. © 2011 Elsevier Inc. (literal)

Prodotto di

• Institute of neurological sciences (ISN) (Istituto)
• Markers molecolari nelle malattie ereditarie e tumori del Sistema Nervoso (ME.P02.011.001) (Modulo)

Autore CNR

• ANTONIO BERRETTA (Unità di personale esterno)
• MARIA VINCENZA CATANIA (Unità di personale interno)
• SIMONA D'ANTONI (Persona)

Insieme di parole chiave

• Parole chiave di "A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Markers molecolari nelle malattie ereditarie e tumori del Sistema Nervoso (ME.P02.011.001) (Modulo)

Autore CNR di

• MARIA VINCENZA CATANIA (Unità di personale interno)
• ANTONIO BERRETTA (Unità di personale esterno)
• SIMONA D'ANTONI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurobiology of disease (Rivista)

Insieme di parole chiave di

• Parole chiave di "A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death" (Insieme di parole chiave)