Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.nbd.2014.12.002 (literal)

Alternative label

• Eleonora Aronica, Frank Baas, Anand Iyer, Anneloor L.M.A. ten Asbroek, Giovanna Morello, Sebastiano Cavallaro (2014)
  Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex
  in Neurobiology of disease
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Eleonora Aronica, Frank Baas, Anand Iyer, Anneloor L.M.A. ten Asbroek, Giovanna Morello, Sebastiano Cavallaro (literal)

Pagina inizio

• 359 (literal)

Pagina fine

• 376 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0969996114003738 (literal)

Rivista

• Neurobiology of disease (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of (Neuro) Pathology, Academic Medical Center, Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands; Department of Neurogenetics, Academic Medical Center, Amsterdam, The Netherlands; Department of (Neuro) Pathology, Academic Medical Center, Amsterdam, The Netherlands;Department of Neurogenetics, Academic Medical Center, Amsterdam, The Netherlands; Functional Genomics Center, Institute of Neurological Sciences, Italian National Research Council, Catania, Italy. (literal)

Titolo

• Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex (literal)

Abstract

• Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. Although 10% of ALS cases are familial (FALS), the majority are sporadic (SALS) and probably associated to a multifactorial etiology. Currently there is no cure or prevention for ALS. A prerequisite to formulating therapeutic strategies is gaining understanding of its etio-pathogenic mechanisms. In this study we analyzed whole-genome expression profiles of 41 motor cortex samples of control (10) and sporadic ALS (31) patients. Unsupervised hierarchical clustering was able to separate control from SALS patients. In addition, SALS patients were subdivided in two different groups that were associated to different deregulated pathways and genes, some of which were previously associated to familiar ALS. These experiments are the first to highlight the genomic heterogeneity of sporadic ALS and reveal new clues to its pathogenesis and potential therapeutic targets. (literal)

Prodotto di

• Institute of neurological sciences (ISN) (Istituto)
• Genomica funzionale delle malattie ereditarie del sistema nervoso (ME.P05.010.001) (Modulo)

Autore CNR

• SEBASTIANO CAVALLARO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• SEBASTIANO CAVALLARO (Unità di personale interno)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Genomica funzionale delle malattie ereditarie del sistema nervoso (ME.P05.010.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurobiology of disease (Rivista)

Insieme di parole chiave di

• Keywords of "Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex" (Insieme di parole chiave)