NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s12031-014-0335-2 (literal)

Alternative label

• D'Amico, Agata Grazia; Scuderi, Soraya; Maugeri, Grazia; Cavallaro, Sebastiano; Drago, Filippo; D'Agata, Velia (2014)
  NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia
  in Journal of molecular neuroscience
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D'Amico, Agata Grazia; Scuderi, Soraya; Maugeri, Grazia; Cavallaro, Sebastiano; Drago, Filippo; D'Agata, Velia (literal)

Pagina inizio

• 405 (literal)

Pagina fine

• 413 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 54 (literal)

Rivista

• Journal of molecular neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Catania; University of Catania; Italian Natl Res Council (literal)

Titolo

• NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia (literal)

Abstract

• Hyperglycemia has been identified as a risk factor responsible for micro- and macrovascular complications in diabetes. NAP (Davunetide) is a peptide whose neuroprotective actions are widely demonstrated, although its biological role on endothelial dysfunctions induced by hyperglycemia remains uninvestigated. In the present study we hypothesized that NAP could play a protective role on hyperglycemia-induced endothelial cell proliferation. To this end we investigated the effects of NAP on an in vitro model of murine microvascular endothelial cells grown in high glucose for 7 days. The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and cyclin D1 protein expression analysis revealed that NAP treatment significantly reduces viability and proliferation of the cells. Hyperglycemia induced the activation of mitogen-activated protein kinase/extracellular signal-regulated protein kinase and/or phosphatidylinositol-3 kinase/Akt pathways in a time-dependent manner. NAP treatment reduced the phosphorylation levels of ERK and AKT in cells grown in high glucose. These evidences suggest that NAP might be effective in the regulation of endothelial dysfunction induced by hyperglycemia. (literal)

Prodotto di

• Genomica funzionale delle malattie ereditarie del sistema nervoso (ME.P05.010.001) (Modulo)
• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• SEBASTIANO CAVALLARO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• SEBASTIANO CAVALLARO (Unità di personale interno)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Genomica funzionale delle malattie ereditarie del sistema nervoso (ME.P05.010.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of molecular neuroscience (Rivista)

Insieme di parole chiave di

• Keywords of "NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia" (Insieme di parole chiave)