Genomic analysis of transcriptional changes underlying neuronal apoptosis. (Contributo in volume (capitolo o saggio))

Type
Label
  • Genomic analysis of transcriptional changes underlying neuronal apoptosis. (Contributo in volume (capitolo o saggio)) (literal)
Anno
  • 2015-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/978-1-4939-2152-2_11 (literal)
Alternative label
  • Cavallaro, Sebastiano (2015)
    Genomic analysis of transcriptional changes underlying neuronal apoptosis.
    in Neuronal Cell Death, 2015
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cavallaro, Sebastiano (literal)
Pagina inizio
  • 141 (literal)
Pagina fine
  • 51 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://link.springer.com/protocol/10.1007%2F978-1-4939-2152-2_11 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
  • Neuronal Cell Death (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana
  • 1254 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Functional Genomics Center, Institute of Neurological Sciences, Italian National Research Council (CNR), Via Paolo Gaifami 18, Catania, 95126, Italy, sebastiano.cavallaro@cnr.it. (literal)
Titolo
  • Genomic analysis of transcriptional changes underlying neuronal apoptosis. (literal)
Abstract
  • Neuronal apoptosisapoptosis represents an intrinsic suicide program, by which a neuronneuron orchestrates its own destruction. Although engagement of apoptosis requires transcriptiontranscription and protein synthesisprotein synthesis , the complete spectrum of genesgenes involved in distinct temporal domains remained unknown until the advent of genomicsgenomics . In the last 10 years, the genome sequences and the developmentdevelopment of high-throughput genomic technologiesgenomic technologies , such as DNA microarraysDNA microarrays , have offered the unprecedented experimental opportunities to explore the transcriptional mechanisms underlying apoptosis from a new systems-level perspective. This review goes over this genomic approach and illustrates the use of microarraymicroarray methodology to dissecting the multigenic program underlying neuronal apoptosis. (literal)
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