http://www.cnr.it/ontology/cnr/individuo/prodotto/ID301800
An effective and rapid determination by MALDI/TOF/TOF of methionine sulphoxide content of ApoA-I in type 2 diabetic patients (Articolo in rivista)
- Type
- Label
- An effective and rapid determination by MALDI/TOF/TOF of methionine sulphoxide content of ApoA-I in type 2 diabetic patients (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/jms.3113 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Seraglia R.; Sartore G.; Marin R.; Burlina S.; Manzato E.; Ragazzi E.; Traldi P.; Lapolla A. (literal)
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- http://onlinelibrary.wiley.com/doi/10.1002/jms.3113/abstract (literal)
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- Rivista
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- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1,7 : CNR-ISTM, Corso Stati Uniti 4, I-35127 Padova, Italy /
2-5,8 : Dipartimento di Medicina, Università di Padova, Padova, Italy /
6 : Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Meneghetti 2, Padova, Italy (literal)
- Titolo
- An effective and rapid determination by MALDI/TOF/TOF of methionine sulphoxide content of ApoA-I in type 2 diabetic patients (literal)
- Abstract
- Increased oxidation of low density lipoprotein (LDL) is characteristic of atherosclerosis. In this frame, high density lipoproteins (HDL) play an important role, being able to remove lipid peroxides (LPOs) and cholesterol from oxidized LDL, so exhibiting a protective role against atherosclerosis. A wide range of reactive compounds lead to the oxidation of methionine (Met) residues with the formation of methionine sulphoxide (MetO) in apolipoprotein A-I (ApoA-I). Consequently, the determination of MetO level can give both an evaluation of oxidative stress and the reduced capability of ApoA-I in LPOs and cholesterol transport. For these reasons, the development of analytical methods able to determine the MetO level is surely of interest, and we report here the results obtained by MALDI mass spectrometry. Copyright © 2013 John Wiley & Sons, Ltd. Copyright © 2013 John Wiley & Sons, Ltd. (literal)
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