http://www.cnr.it/ontology/cnr/individuo/prodotto/ID301293

Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (Articolo in rivista)

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Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (Articolo in rivista) (literal)

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Grasso, Giuseppa Ida; Arena, Giuseppe Enrico; Bellia, Francesco; Rizzarelli, Enrico; Vecchio, Graziella (2014)
Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound
in Journal of inorganic biochemistry
(literal)

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Grasso, Giuseppa Ida; Arena, Giuseppe Enrico; Bellia, Francesco; Rizzarelli, Enrico; Vecchio, Graziella (literal)

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Istituto di Biostrutture e Bioimmagini - Consiglio Nazionale delle Ricerche; Dipartimento di Scienze Chimiche - Universita degli Studi di Catania (literal)

Titolo

Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (literal)

Abstract

Homocarnosine is an endogenous dipeptide distributed in cerebral regions and cerebrospinal fluid. Homocarnosine may serve as an antioxidant, free radical scavenger, neurotransmitter, buffering system and metal chelating agent, especially for copper(II) and zinc(II). The homeostasis of homocarnosine is regulated by carnosinases; the serum-circulating isoform of these metallodipeptidases partially hydrolyses homocarnosine in the blood. The enzyme activity is also inhibited by homocarnosine itself in a dose-dependent manner. We synthesized a new multifunctional homocarnosine derivative with trehalose, a disaccharide that possesses several beneficial properties, among which the inhibition of protein aggregation (i.e. A? amyloid and polyglutamine proteins) involved in widespread neurodegenerative disorders. We studied the copper(II) binding features of the new conjugate by means of potentiometric and spectroscopic techniques (UV-visible and circular dichroism) and the superoxide dismutase-like activity of the copper(II) complexes with homocarnosine and its trehalose conjugate was evaluated. The inhibitory effect of the new homocarnosine derivative on the carnosinase activity and its effects on A? aggregation were also investigated. © 2013 Elsevier Inc. (literal)

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