The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/jms.3338 (literal)

Alternative label

• Bellia, Francesco; Grasso, Giuseppe (2014)
  The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme
  in Journal of mass spectrometry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bellia, Francesco; Grasso, Giuseppe (literal)

Pagina inizio

• 274 (literal)

Pagina fine

• 279 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/record/display.url?eid=2-s2.0-84898465095&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 49 (literal)

Rivista

• Journal of mass spectrometry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Biostrutture e Bioimmagini - CNR Dipartimento di Scienze Chimiche, Università degli Studi di Catania (literal)

Titolo

• The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (literal)

Abstract

• Amylin or islet amyloid polypeptide (IAPP) is a 37-residue peptide hormone secreted from the pancreatic islets into the blood circulation and is cleared by peptidases in the kidney. IAPP aggregates are strongly associated with ?-cell degeneration in type 2 diabetes, as demonstrated by the fact that more than 95% of patients exhibit IAPP amyloid upon autopsy. Recently, it has been reported that metal ions such as copper(II) and zinc(II) are implicated in the aggregation of IAPP as well as able to modulate the proteolytic activity of IAPP degrading enzymes. For this reason, in this work, the role of the latter metal ions in the degradation of IAPP by insulin-degrading enzyme (IDE) has been investigated by a chromatographic and mass spectrometric combined method. The latter experimental approach allowed not only to assess the overall metal ion inhibition of the human and murine IAPP degradation by IDE but also to have information on copper- and zinc-induced changes in IAPP aggregation. In addition, IDE cleavage site preferences in the presence of metal ions are rationalized as metal ion-induced changes in substrate accessibility. © 2014 John Wiley & Sons, Ltd. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• FRANCESCO BELLIA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR di

• FRANCESCO BELLIA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of mass spectrometry (Rivista)

Insieme di parole chiave di

• Parole chiave di "The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme" (Insieme di parole chiave)