Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1371/journal.pgen.1003611 (literal)

Alternative label

• Oksenych V, Zhovmer A, Ziani S, Mari P-O, Eberova J, Nardo T, Stefanini M, Giglia-Mari G, Egly J-M, Coin F. (2013)
  Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack
  in PLOS genetics (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Oksenych V, Zhovmer A, Ziani S, Mari P-O, Eberova J, Nardo T, Stefanini M, Giglia-Mari G, Egly J-M, Coin F. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84880790091&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• PLOS genetics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 7 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IGBMC, Department of Functional Genomics and Cancer, CNRS/INSERM/Université de Strasbourg, C. U, Strasbourg, France; Université de Toulouse, UPS, IPBS, Toulouse, France; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy (literal)

Titolo

• Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack (literal)

Abstract

• UV-induced DNA damage causes repression of RNA synthesis. Following the removal of DNA lesions, transcription recovery operates through a process that is not understood yet. Here we show that knocking-out of the histone methyltransferase DOT1L in mouse embryonic fibroblasts (MEF(DOT1L)) leads to a UV hypersensitivity coupled to a deficient recovery of transcription initiation after UV irradiation. However, DOT1L is not implicated in the removal of the UV-induced DNA damage by the nucleotide excision repair pathway. Using FRAP and ChIP experiments we established that DOT1L promotes the formation of the pre-initiation complex on the promoters of UV-repressed genes and the appearance of transcriptionally active chromatin marks. Treatment with Trichostatin A, relaxing chromatin, recovers both transcription initiation and UV-survival. Our data suggest that DOT1L secures an open chromatin structure in order to reactivate RNA Pol II transcription initiation after a genotoxic attack. (literal)

Prodotto di

• Institute of molecular genetics (IGM) (Istituto)
• Malattie genetiche dovute a difetti nella riparazione del DNA che predispongono ai tumori. Analisi genetica funzionale dei fattori importanti per l'integrità del genoma. (ME.P05.005.001) (Modulo)

Autore CNR

• TIZIANA NARDO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Malattie genetiche dovute a difetti nella riparazione del DNA che predispongono ai tumori. Analisi genetica funzionale dei fattori importanti per l'integrità del genoma. (ME.P05.005.001) (Modulo)

Autore CNR di

• TIZIANA NARDO (Unità di personale interno)
• http://www.cnr.it/ontology/cnr/individuo/unitaDiPersonaleEsterno/ID24128

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PLOS genetics (Rivista)