Copper(II) interaction with amyloid-beta: Affinity and speciation (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Copper(II) interaction with amyloid-beta: Affinity and speciation (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ccr.2011.07.012 (literal)

Alternative label

• Arena, Giuseppe; Pappalardo, Giuseppe; Sovago, Imre; Rizzarelli, Enrico (2012)
  Copper(II) interaction with amyloid-beta: Affinity and speciation
  in Coordination chemistry reviews (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Arena, Giuseppe; Pappalardo, Giuseppe; Sovago, Imre; Rizzarelli, Enrico (literal)

Pagina inizio

• 3 (literal)

Pagina fine

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 256 (literal)

Rivista

• Coordination chemistry reviews (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1-2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Chemical Sciences, University of Catania; CNR-Institute of Biostructure and Bioimaging Catania; Department of Inorganic and Analytical Chemistry, University of Debrecen. (literal)

Titolo

• Copper(II) interaction with amyloid-beta: Affinity and speciation (literal)

Abstract

• Numerous conflicting values have been proposed regarding the affinity of Cu2+ for amyloid-beta (A beta) peptide, the causative agent of Alzheimer's disease. In the present review, we critically compare the two approaches employed so far (the K-d and the stability constant approach) to express the affinity of copper(II) for the amyloid-beta (A beta) peptide and highlight the limits and the advantages of the two approaches. We also analyze the conditions employed for some experiments, which we have taken as examples, highlighting some of the points that may have generated the deriving divergent propositions. Through the analysis of the species distribution, we show the implications that a correct speciation may have on data interpretation as well as on experiment planning. By doing so, this review aims at shifting the perspective on the binding issue from the classic K-d approach, based on low and high affinity binding sites - often referred to as component I and II, or form land II - to stoichiometry determination and, as a consequence, to the speciation of Cu-A beta complexes. Additionally, this review has the purpose of demonstrating that a quantitative assessment of the coordination sphere is complicated by the variety of equilibria often occurring over a relatively narrow pH range. (C) 2011 Elsevier B.V. All rights reserved. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)

Autore CNR

• GIUSEPPE PAPPALARDO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Copper(II) interaction with amyloid-beta: Affinity and speciation" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIUSEPPE PAPPALARDO (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Coordination chemistry reviews (Rivista)

Insieme di parole chiave di

• Keywords of "Copper(II) interaction with amyloid-beta: Affinity and speciation" (Insieme di parole chiave)