Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.yebeh.2013.05.002 (literal)

Alternative label

• Russo, Emilio; Chimirri, Serafina; Aiello, Rossana; De Fazio, Salvatore; Leo, Antonio; Rispoli, Vincenzo; Marra, Rosario; Labate, Angelo; De Fazio, Pasquale; Citraro, Rita; De Sarro, Giovambattista (2013)
  Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures
  in Epilepsy & behavior (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Russo, Emilio; Chimirri, Serafina; Aiello, Rossana; De Fazio, Salvatore; Leo, Antonio; Rispoli, Vincenzo; Marra, Rosario; Labate, Angelo; De Fazio, Pasquale; Citraro, Rita; De Sarro, Giovambattista (literal)

Pagina inizio

• 232 (literal)

Pagina fine

• 240 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 28 (literal)

Rivista

• Epilepsy & behavior (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Magna Graecia University of Catanzaro; Magna Graecia University of Catanzaro; Consiglio Nazionale delle Ricerche (CNR); Magna Graecia University of Catanzaro (literal)

Titolo

• Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures (literal)

Abstract

• Several clinical and preclinical studies have focused on the relationship between epilepsy and psychological disturbances. Although behavior in some experimental models of epilepsy has been studied, only few of them can be considered as models of epilepsy and mood disorder comorbidity. Since several models of epilepsy or psychiatric disorders are already available, we wondered whether a mixture of the two could experimentally represent a valid alternative to study such comorbidity. Here, we present a possible experimental protocol to study drug effects and physiopathogenesis of psychiatric comorbidity in epileptic animals. Pentylentetrazol-kindled animals were subjected to the chronic mild stress (CMS) procedure; furthermore, we tested the effects of chronic lamotrigine treatment on the development of comorbidity. We found that epileptic-depressed animals showed more pronounced behavioral alterations in comparison to other mice groups, indicating that kindled animals develop more pronounced CMS-induced behavioral alterations than nonepileptic mice; lamotrigine was able to prevent the development of comorbidities such as anxiety, depression-like behavior, and memory impairment. (C) 2013 Elsevier Inc. All rights reserved. (literal)

Prodotto di

• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• ROSARIO MARRA (Persona)

Insieme di parole chiave

• Keywords of "Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of neurological sciences (ISN) (Istituto)

Autore CNR di

• ROSARIO MARRA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Epilepsy & behavior (Rivista)

Insieme di parole chiave di

• Keywords of "Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures" (Insieme di parole chiave)