Metabolic syndrome and the immunological affair with the blood-brain barrier. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Metabolic syndrome and the immunological affair with the blood-brain barrier. (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Alternative label

• Mauro C1, De Rosa V2, Marelli-Berg F1, Solito E1. (2015)
  Metabolic syndrome and the immunological affair with the blood-brain barrier.
  in Frontiers in immunology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mauro C1, De Rosa V2, Marelli-Berg F1, Solito E1. (literal)

Rivista

• Frontiers in immunology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London , UK. 2Istituto Per L'Endocrinologia e L'Oncologia Sperimentale \"G.Salvatore\" - Consiglio Nazionale delle Ricerche (IEOS-CNR) , Naples , Italy. (literal)

Titolo

• Metabolic syndrome and the immunological affair with the blood-brain barrier. (literal)

Abstract

• Epidemiological studies reveal an increased incidence of obesity worldwide, which is associated with increased prevalence and severity of cognitive disorders. The blood-brain barrier (BBB) represents the interface between the peripheral circulation and the brain, and plays a fundamental role in the cross-talk between these two compartments. The homeostatic function of the BBB is the protection of the brain from peripheral insult/inflammation. Alterations in the function of the BBB lead to pathologies of the central nervous system. Recently, metabolic imbalance has been shown to be an important risk factor associated with the decline of BBB integrity and function. This has direct etiological consequences on a variety of cerebrovascular and neurodegenerative pathologies with great impact to society. Priority areas for future preclinical research include strategies to improve clinicians' ability to diagnose, prevent, and manage BBB abnormalities. In sharp contrast with epidemiological studies and clinical needs, little is known about the mechanisms that link metabolic syndrome to BBB functionality and cognitive disorders. Our view is that immune responses caused by metabolic stress might play a major role in this conundrum. (literal)

Prodotto di

• Correlazione tra sistema immunitario e sistema endocrino: modelli di alterata funzione del sistema immunitario come causa di patologie (SV.P16.001.001) (Modulo)
• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• VERONICA DE ROSA (Unità di personale interno)

Incoming links:

Prodotto

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)
• Correlazione tra sistema immunitario e sistema endocrino: modelli di alterata funzione del sistema immunitario come causa di patologie (SV.P16.001.001) (Modulo)

Autore CNR di

• VERONICA DE ROSA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Frontiers in immunology (Rivista)