L-DOPA preloading increases the uptake of borophenylalanine in C6 glioma rat model: A new strategy to improve BNCT efficacy (Articolo in rivista)

Type
Label
  • L-DOPA preloading increases the uptake of borophenylalanine in C6 glioma rat model: A new strategy to improve BNCT efficacy (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ijrobp.2008.06.1493 (literal)
Alternative label
  • Capuani, S; Gili, T; Bozzali, M; Russo, S; Porcari, P; Camet-Ri, C; D'Amore, E; Colasanti, M; Venturini, G; Maraviglia, B; Lazzartno, G; Pastore, FS (2008)
    L-DOPA preloading increases the uptake of borophenylalanine in C6 glioma rat model: A new strategy to improve BNCT efficacy
    in International journal of radiation oncology, biology, physics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Capuani, S; Gili, T; Bozzali, M; Russo, S; Porcari, P; Camet-Ri, C; D'Amore, E; Colasanti, M; Venturini, G; Maraviglia, B; Lazzartno, G; Pastore, FS (literal)
Pagina inizio
  • 562 (literal)
Pagina fine
  • 567 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 72 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • \"[Capuani, Silvia; Gili, Tommaso; Maraviglia, Bruno] Enrico Fermi Ctr, Rome, Italy; [Bozzali, Marco] Santa Lucia Fdn, Neuroimaging Lab, Rome, Italy; [Russo, Salvatore] Univ S Manchester Hosp, Dept Neurosurg, Manchester M20 8LR, Lancs, England; [D'Amore, Emanuela] Ist Super Sanita, Serv Qualita & Sieurezza Sperimentaz Anim, I-00161 Rome, Italy; [Colasanti, Marco; Venturini, Giorgio] Univ Rome III, Dept Biol Sci, Rome, Italy; [Lazzartno, Giuseppe] Univ Catania, Dept Chem Sci, Biochem Lab, Catania, Italy; [Pastore, Francesco S.] Univ Roma Tor Vergata, Dept Neurosurg, Rome, Italy; [Capuani, Silvia; Gili, Tommaso; Porcari, Paola; Camet-Ri, Cesare] Univ Roma La Sapienza, INFM CNR CRS SOFT, Rome, Italy (literal)
Titolo
  • L-DOPA preloading increases the uptake of borophenylalanine in C6 glioma rat model: A new strategy to improve BNCT efficacy (literal)
Abstract
  • \"Purpose: Boron neutron capture therapy (BNCT) is a radiotherapeutic modality based on B-10(n, alpha)Li-7 reaction, for the treatment of malignant gliomas. One of the main limitations for BNCT effectiveness is the insufficient intake of B-10 nuclei in the tumor cells. This work was aimed at investigating the use of L-DOPA as a putative enhancer for B-10-drug 4-dihydroxy-borylphenylaianine (BPA) uptake in the C6-glioma model. The investigation was first performed in vitro and then extended to the animal model. Methods and Materials: BPA accumulation in C6-glioma cells was assessed using radiowave dielectric spectroscopy, with and without L-DOPA preloading. Two L-DOPA incubation times (2 and 4 hours) were investigated, and the corresponding effects on BPA accumulation were quantified. C6-glioma cells were also implanted in the brain of 32 rats, and tumor growth was monitored by magnetic resonance imaging. Rats were assigned to two experimental branches: (1) BPA administration; (2) BPA administration after pretreatment with L-DOPA. All animals were sacrificed, and assessments of BPA concentrations in tumor tissue, normal brain, and blood samples were performed using high-performance liquid chromatography. Results: L-DOPA preloading induced a massive increase of BPA concentration in C6-glioma cells only after a 4-hour incubation. In the animal model, L-DOPA pretreatment produced a significantly higher accumulation of BPA in tumor tissue but not in normal brain and blood samples. Conclusions: This study suggests the potential use of L-DOPA as enhancer for BPA accumulation in malignant gliomas eligible for BNCT. L-DOPA preloading effect is discussed in terms of membrane transport mechanisms. (C) 2008 Elsevier Inc.\" (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it