Bioinspired porous membranes containing polymer nanoparticles for wound healing (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Bioinspired porous membranes containing polymer nanoparticles for wound healing (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/jbm.a.35121 (literal)

Alternative label

• Ferreira, Ana M.; Mattu, Clara; Ranzato, Elia; Ciardelli, Gianluca (2014)
  Bioinspired porous membranes containing polymer nanoparticles for wound healing
  in Journal of biomedical materials research. Part A
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ferreira, Ana M.; Mattu, Clara; Ranzato, Elia; Ciardelli, Gianluca (literal)

Pagina inizio

• 4394 (literal)

Pagina fine

• 4405 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 102 (literal)

Rivista

• Journal of biomedical materials research. Part A (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 12 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Polytechnic University of Turin; University of Eastern Piedmont Amedeo Avogadro; Consiglio Nazionale delle Ricerche (CNR) (literal)

Titolo

• Bioinspired porous membranes containing polymer nanoparticles for wound healing (literal)

Abstract

• Skin damages covering a surface larger than 4 cm(2) require a regenerative strategy based on the use of appropriate wound dressing supports to facilitate the rapid tissue replacement and efficient self-healing of the lost or damaged tissue. In the present work, A novel biomimetic approach is proposed for the design of a therapeutic porous construct made of poly(l-lactic acid) (PLLA) fabricated by thermally induced phase separation (TIPS). Biomimicry of ECM was achieved by immobilization of type I collagen through a two-step plasma treatment for wound healing. Anti-inflammatory (indomethacin)-containing polymeric nanoparticles (nps) were loaded within the porous membranes in order to minimize undesired cell response caused by post-operative inflammation. The biological response to the scaffold was analyzed by using human keratinocytes cell cultures. In this work, a promising biomimetic construct for wound healing and soft tissue regeneration with drug-release properties was fabricated since it shows (i) proper porosity, pore size, and mechanical properties, (ii) biomimicry of ECM, and (iii) therapeutic potential. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 4394-4405, 2014. (literal)

Prodotto di

• Istituto per i processi chimico-fisici (IPCF) (Istituto)
• Progettazione, preparazione e proprietà di materiali polimerici multifasici e/o funzionali a struttura e composizione modulabile (MD.P01.026.001) (Modulo)

Autore CNR

• GIANLUCA CIARDELLI (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Bioinspired porous membranes containing polymer nanoparticles for wound healing" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto per i processi chimico-fisici (IPCF) (Istituto)
• Progettazione, preparazione e proprietà di materiali polimerici multifasici e/o funzionali a struttura e composizione modulabile (MD.P01.026.001) (Modulo)

Autore CNR di

• GIANLUCA CIARDELLI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of biomedical materials research. Part A (Rivista)

Insieme di parole chiave di

• Keywords of "Bioinspired porous membranes containing polymer nanoparticles for wound healing" (Insieme di parole chiave)