High-sensitivity C-reactive Protein is a Predictive Factor of Adiposity in Children: Results of the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) Study (Articolo in rivista)

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  • High-sensitivity C-reactive Protein is a Predictive Factor of Adiposity in Children: Results of the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) Study (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1161/JAHA.113.000101 (literal)
Alternative label
  • Nappo A, Iacoviello L, Fraterman A, Gonzalez-Gil EM, Hadjigeorgiou C, Marild S, Molnar D, Moreno LA, Peplies J, Sioen I, Veidebaum T, Siani A, Russo P. (2013)
    High-sensitivity C-reactive Protein is a Predictive Factor of Adiposity in Children: Results of the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) Study
    in Journal of the American Heart Association
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Nappo A, Iacoviello L, Fraterman A, Gonzalez-Gil EM, Hadjigeorgiou C, Marild S, Molnar D, Moreno LA, Peplies J, Sioen I, Veidebaum T, Siani A, Russo P. (literal)
Pagina inizio
  • e000101 (literal)
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  • 2 (literal)
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  • 8 (literal)
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  • 3 (literal)
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  • ISI Web of Science (WOS) (literal)
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  • From the Unit of Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy (A.N., A.S., P.R.); Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, Fondazione di Ricerca e Cura \"Giovanni Paolo II\", Università Cattolica, Campobasso, Italy (L.I.); Medizinisches Versorgungszentrum Dr Eberhard & Partner Dortmund, Laboratoriumsmedizin Dortmund, Dortmund, Germany (A.F.); Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza, Zaragoza, Spain (E.M.G., L.A.M.); Research and Education Institute of Child Health, Strovolos, Cyprus (C.H.); Department of Pediatrics, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden (S.M.); Department of Pediatrics, Medical Faculty, University of P?ecs, P?ecs, Hungary (D.M.); BIPS - Institute for Epidemiology and Prevention Research, Bremen, Germany (J.P.); Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (I.S.); Research Foundation - Flanders, Brussels, Belgium (I.S.); National Institute for Health Development, Tallinn, Estonia (T.V.). (literal)
Titolo
  • High-sensitivity C-reactive Protein is a Predictive Factor of Adiposity in Children: Results of the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) Study (literal)
Abstract
  • Background---Whereas cross-sectional studies have shown that obesity is associated with increased C-reactive protein (CRP) levels in children, little is known about the impact of low-grade inflammation on body mass changes during growth. Methods and Results---We assessed cross-sectionally and longitudinally the association of high-sensitivity (hs)-CRP levels with overweight/obesity and related cardiometabolic risk factors in the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) cohort. 16 224 children from 8 European countries (2 to 9 years) were recruited during the baseline survey (T0). After the exclusion of 7187 children because of missing hs-CRP measurements and 2421 because of drug use during the previous week, the analysis was performed on 6616 children (Boys=3347; Girls=3269; age=6.3?1.7 years). Of them, 4110 were reexamined 2 years later (T1). Anthropometric variables, blood pressure, hs-CRP, blood lipids, glucose and insulin were measured. The population at T0 was divided into 3 categories, according to the baseline hs-CRP levels. Higher hs-CRP levels were associated with significantly higher prevalence of overweight/obesity, body mass index (BMI) z-score and central adiposity indices (P values all <0.0001), and with higher blood pressure and lower HDL-cholesterol levels. Over the 2-year followup, higher baseline hs-CRP levels were associated with a significant increase in BMI z-score (P<0.001) and significantly higher risk of incident overweight/obesity. Conclusions---Higher hs-CRP levels are associated to higher body mass and overweight/obesity risk in a large population of European children. Children with higher baseline levels of hs-CRP had a greater increase in BMI z-score and central adiposity over time and were at higher risk of developing overweight/obesity during growth (literal)
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