Cytotoxicity of alpha-dicarbonyl compounds submitted to in vitro simulated digestion process (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Cytotoxicity of alpha-dicarbonyl compounds submitted to in vitro simulated digestion process (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.foodchem.2012.10.063 (literal)

Alternative label

• Amoroso A, Maga G, Daglia M. (2013)
  Cytotoxicity of alpha-dicarbonyl compounds submitted to in vitro simulated digestion process
  in Food chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Amoroso A, Maga G, Daglia M. (literal)

Pagina inizio

• 654 (literal)

Pagina fine

• 659 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84878015486&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 140 (literal)

Rivista

• Food chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Molecular Genetics, IGM, CNR, via Abbiategrasso 207, 27100 Pavia, Italy; Department of Drug Sciences, University of Pavia, via Taramelli 12, 27100 Pavia, Italy (literal)

Titolo

• Cytotoxicity of alpha-dicarbonyl compounds submitted to in vitro simulated digestion process (literal)

Abstract

• ?-Dicarbonyl compounds (?-DCs), such as glyoxal, methylglyoxal and 2,3-butanedione, are highly reactive substances occurring in thermally treated and fermented foods, that may react with amino and sulphydryl groups of side chains of proteins to form Maillard reaction end products, inducing a negative impact on the digestibility and on nutritional value of protein. In recent years the role of food derived ?-DCs in gastroduodenal tract is under investigation to understand whether excess consumption of such dietary compounds might be a risk for human health. In this study the interactions between a mixture of glyoxal, methylglyoxal and 2,3-butanedione and the digestive enzymes (pepsin and pancreatin) were studied. The results showed that during gastroduodenal digestion ?-DCs react with digestive enzymes to produce carbonylated proteins. Moreover, undigested and digested ?-DC cytotoxicity against human cells, as well as their ability to inhibit the function of human enzymes responsible for DNA repair were shown. © 2012 Elsevier Ltd. All rights reserved. (literal)

Prodotto di

• Sviluppo e meccanismo d'azione di analoghi nucleotidici e nucleosidici come composti antiproliferativi e antivirali : nuovi composti e nuovi bersagli per la terapia (ME.P04.004.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• GIOVANNI MAGA (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Cytotoxicity of alpha-dicarbonyl compounds submitted to in vitro simulated digestion process" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Sviluppo e meccanismo d'azione di analoghi nucleotidici e nucleosidici come composti antiproliferativi e antivirali : nuovi composti e nuovi bersagli per la terapia (ME.P04.004.001) (Modulo)

Autore CNR di

• GIOVANNI MAGA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Food chemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Cytotoxicity of alpha-dicarbonyl compounds submitted to in vitro simulated digestion process" (Insieme di parole chiave)