Pathway landscape and regulatory networks of epigenetic regulation in breast cancer and melanoma. Theoretical Biology and Medical Modelling (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Pathway landscape and regulatory networks of epigenetic regulation in breast cancer and melanoma. Theoretical Biology and Medical Modelling (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1186/1742-4682-11-S1-S8 (literal)

Alternative label

• Mariama El Baroudi, Dario La Sala, Caterina Cinti,Enrico Capobianco (2014)
  Pathway landscape and regulatory networks of epigenetic regulation in breast cancer and melanoma. Theoretical Biology and Medical Modelling
  in Theoretical biology and medical modelling
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mariama El Baroudi, Dario La Sala, Caterina Cinti,Enrico Capobianco (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 11 (literal)

Rivista

• Theoretical biology and medical modelling (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IIT-CNR,IFC-CNR, Policlinico Universitario, Palermo (literal)

Titolo

• Pathway landscape and regulatory networks of epigenetic regulation in breast cancer and melanoma. Theoretical Biology and Medical Modelling (literal)

Abstract

• Background Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant. Methods Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in parallel on a few cell lines (MCF-7 for BC and A375 for melanoma). Starting from differential expression after treatment with a demethylating agent, the 5-Aza-2'-deoxycytidine (DAC), we provided pathway enrichment analysis and gene regulatory maps with cross-linked microRNAs and transcription factors. Results Several oncogenic signaling pathways altered upon DAC treatment were detected with significant enrichment. We represented the association between these cancers by depicting the landscape of common and specific variation affecting them. (literal)

Prodotto di

• Istituto di informatica e telematica (IIT) (Istituto)
• Algoritmica per bioinformatica (INT.P02.003.003) (Modulo)

Autore CNR

• CATERINA CINTI (Persona)
• MARIAMA EL BAROUDI (Persona)

Insieme di parole chiave

• Parole chiave di "Pathway landscape and regulatory networks of epigenetic regulation in breast cancer and melanoma. Theoretical Biology and Medical Modelling" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di informatica e telematica (IIT) (Istituto)
• Algoritmica per bioinformatica (INT.P02.003.003) (Modulo)

Autore CNR di

• CATERINA CINTI (Persona)
• MARIAMA EL BAROUDI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Theoretical biology and medical modelling (Rivista)

Insieme di parole chiave di

• Parole chiave di "Pathway landscape and regulatory networks of epigenetic regulation in breast cancer and melanoma. Theoretical Biology and Medical Modelling" (Insieme di parole chiave)