Functional correlates of preserved naming performance in amnestic Mild Cognitive Impairment. (Articolo in rivista)

Type
Label
  • Functional correlates of preserved naming performance in amnestic Mild Cognitive Impairment. (Articolo in rivista) (literal)
Anno
  • 2015-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.neuropsychologia.2014.09.041 (literal)
Alternative label
  • Eleonora Catricalà a,1, Pasquale A. Della Rosa b,1, Laura Parisi c, Antonio G. Zippo b, Virginia M. Borsa c, Antonella Iadanza d, Isabella Castiglioni b, Andrea Falini d, Stefano F. Cappa c,e (2015)
    Functional correlates of preserved naming performance in amnestic Mild Cognitive Impairment.
    in Neuropsychologia (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Eleonora Catricalà a,1, Pasquale A. Della Rosa b,1, Laura Parisi c, Antonio G. Zippo b, Virginia M. Borsa c, Antonella Iadanza d, Isabella Castiglioni b, Andrea Falini d, Stefano F. Cappa c,e (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://dx.doi.org/10.1016/j.neuropsychologia.2015.01.009i (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • These authors contributed equally to this work. a. Laboratory of Neuropsychology, IRCCS Istituto Neurologico Carlo Besta, Milano, Italy b. Institute of Molecular Bioimaging and Physiology (IBFM)-CNR, Milano, Italy c. Division of Neuroscience, San Raffaele Scientific Institute, Milano, Italy d. Experimental Psychology Research Department, Division of Psychology and Language Sciences, University College London, London, England e. Institute for Advanced Study IUSS Pavia, Pavia, Italy (literal)
Titolo
  • Functional correlates of preserved naming performance in amnestic Mild Cognitive Impairment. (literal)
Abstract
  • Naming abilities are typically preserved in amnestic Mild Cognitive Impairment (aMCI), a condition associated with increased risk of progression to Alzheimer's disease (AD). We compared the functional correlates of covert picture naming and word reading between a group of aMCI subjects and matched controls. Unimpaired picture naming performance was associated with more extensive activations, in particular involving the parietal lobes, in the aMCI group. In addition, in the condition associated with higher processing demands (blocks of categorically homogeneous items, living items), increased activity was observed in the aMCI group, in particular in the left fusiform gyrus. Graph analysis provided further evidence of increased modularity and reduced integration for the homogenous sets in the aMCI group. The functional modifications associated with preserved performance may reflect, in the case of more demanding tasks, compensatory mechanisms for the subclinical involvement of semantic processing areas by AD pathology. (literal)
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