Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity. (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.molimm.2014.04.004 (literal)

Alternative label

• Di Lorenzo, Flaviana; Silipo, Alba; Bianconi, Irene; Lore'; Nicola Ivan; Scamporrino, Andrea; Sturiale, Luisa; Garozzo, Domenico; Lanzetta, Rosa; Parrilli, Michelangelo; Bragonzi, Alessandra; Molinaro, Antonio (2015)
  Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity.
  in Molecular immunology; Elsevier BV, Amsterdam (Paesi Bassi)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Di Lorenzo, Flaviana; Silipo, Alba; Bianconi, Irene; Lore'; Nicola Ivan; Scamporrino, Andrea; Sturiale, Luisa; Garozzo, Domenico; Lanzetta, Rosa; Parrilli, Michelangelo; Bragonzi, Alessandra; Molinaro, Antonio (literal)

Pagina inizio

• 166 (literal)

Pagina fine

• 175 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0161589014000844# (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 63 (literal)

Rivista

• Molecular immunology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Scienze Chimiche, Università di Napoli \"Federico II\", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy Infection and Cystic Fibrosis Unit, San Raffaele Scientific Institute, Milano, Italy Istituto di Chimica e Tecnologia dei Polimeri - ICTP - CNR, Via P. Gaifami 18, 95126 Catania, Italy (literal)

Titolo

• Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity. (literal)

Abstract

• Pseudomonas aeruginosa, the major pathogen involved in lethal infections in cystic fibrosis (CF) population, is able to cause permanent chronic infections that can persist over the years. This ability to chronic colonize CF airways is related to a series of adaptive bacterial changes involving the immunostimulant lipopolysaccharide (LPS) molecule. The structure of LPSs isolated from several P. aeruginosa strains showed conserved features that can undergo chemical changes during the establishment of the chronic infection. In the present paper, we report the elucidation of the structure and the biological activity of the R-LPS (lipooligosaccharide, LOS) isolated from the persistent CF isolate P. aeruginosa strain RP73, in order to give further insights in the adaptation mechanism of the pathogen in the CF environment. The complete structural analysis of P. aeruginosa RP73 LOS was achieved by chemical analyses, NMR spectroscopy and MALDI MS spectrometry, while the assessment of the biological activity was attained testing the in vivo pro-inflammatory capacity of the isolated LOS molecule. While a typical CF LPS is able to trigger a high immune response and production of pro-inflammatory molecules, this P. aeruginosa RP73 LOS showed to possess a low pro-inflammatory capacity. This was possible due to a singular chemical structure possessing an under-acylated lipid A very similar to the LPS of P. aeruginosa found in chronic lung diseases such as bronchiectstasis. (literal)

Editore

• Elsevier BV (Editore)

Prodotto di

• Glicomica e Proteomica per la ricerca di biomarcatori per la diagnosi e la terapia di patologie congenite, tumorali e infiammatorie. (PM.P06.013.001) (Modulo)

Autore CNR

• ANDREA ANTONINO SCAMPORRINO (Persona)
• DOMENICO GAROZZO (Unità di personale interno)
• LUISELLA STURIALE (Persona)

Insieme di parole chiave

• Parole chiave di "Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• DOMENICO GAROZZO (Unità di personale interno)
• LUISELLA STURIALE (Persona)
• ANDREA ANTONINO SCAMPORRINO (Persona)

Prodotto

• Glicomica e Proteomica per la ricerca di biomarcatori per la diagnosi e la terapia di patologie congenite, tumorali e infiammatorie. (PM.P06.013.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular immunology (Rivista)

Editore di

• Elsevier BV (Editore)

Insieme di parole chiave di

• Parole chiave di "Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity." (Insieme di parole chiave)