http://www.cnr.it/ontology/cnr/individuo/prodotto/ID293717
The serotonin receptor 7 and the structural plasticity of brain circuits (Articolo in rivista)
- Type
- Label
- The serotonin receptor 7 and the structural plasticity of brain circuits (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.3389/fnbeh.2014.00318 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Volpicelli F.; Speranza L.; di Porzio U.; Crispino M.; Perrone-Capano C. (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.scopus.com/inward/record.url?eid=2-s2.0-84908211989&partnerID=q2rCbXpz (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
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- Note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Department of Pharmacy, University of Naples Federico II, Naples, Italy;
Institute of Genetics and Biophysics \"Adriano Buzzati Traverso\", National Research Council (CNR), Naples, Italy;
Department of Biology, University of Naples Federico II, Naples, Italy (literal)
- Titolo
- The serotonin receptor 7 and the structural plasticity of brain circuits (literal)
- Abstract
- Serotonin (5-hydroxytryptamine, 5-HT) modulates numerous physiological processes in the nervous system. Together with its function as neurotransmitter, 5-HT regulates neurite outgrowth, dendritic spine shape and density, growth cone motility and synapse formation during development. In the mammalian brain 5-HT innervation is virtually ubiquitous and the diversity and specificity of its signaling and function arise from at least 20 different receptors, grouped in 7 classes. Here we will focus on the role 5-HT7 receptor (5-HT7R) in the correct establishment of neuronal cytoarchitecture during development, as also suggested by its involvement in several neurodevelopmental disorders. The emerging picture shows that this receptor is a key player contributing not only to shape brain networks during development but also to remodel neuronal wiring in the mature brain, thus controlling cognitive and emotional responses. The activation of 5-HT7R might be one of the mechanisms underlying the ability of the CNS to respond to different stimuli by modulation of its circuit configuration. (literal)
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