Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosis in cerebellar granule cells. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosis in cerebellar granule cells. (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s10495-014-1049-1 (literal)

Alternative label

• Bobba A, Amadoro G, La Piana G, Calissano P, Atlante A. (2015)
  Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosis in cerebellar granule cells.
  in Apoptosis (Lond.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bobba A, Amadoro G, La Piana G, Calissano P, Atlante A. (literal)

Pagina inizio

• 10 (literal)

Pagina fine

• 28 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 20 (literal)

Rivista

• Apoptosis (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Biomembrane and Bioenergetics (IBBE) - CNR, Via Amendola 165/A, 70126 Bari, Italy Institute of Translational Pharmacology (IFT) - CNR, Via Fosso del Cavaliere, 100, 00133 Rome, Italy Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, Via Orabona, 4, 70126 Bari, Italy European Brain Research Institute (EBRI), Via del Fosso di Fiorano, 64-65, 00143 Rome, Italy (literal)

Titolo

• Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosis in cerebellar granule cells. (literal)

Abstract

• Alzheimer's disease (AD) and cancer proceed via one or more common molecular mechanisms: a metabolic shift from oxidative phosphorylation to glycolysis-corresponding to the activation of the Warburg effect-occurs in both diseases. The findings reported in this paper demonstrate that, in the early phase of apoptosis, glucose metabolism is enhanced, i.e. key proteins which internalize and metabolize glucose-glucose transporter, hexokinase and phosphofructokinase-are up-regulated, in concomitance with a parallel decrease in oxygen consumption by mitochondria and increase of l-lactate accumulation. Reversal of the glycolytic phenotype occurs in the presence of dichloroacetate, inhibitor of the pyruvate dehydrogenase kinase enzyme, which speeds up apoptosis of cerebellar granule cells, reawakening mitochondria and then modulating glycolytic enzymes. Loss of the adaptive advantage afforded by aerobic glycolysis, which occurs in the late phase of apoptosis, exacerbates the pathological processes underlying neurodegeneration, leading inevitably the cell to death. In conclusion, the data propose that both aerobic, i.e. Warburg effect, essentially due to the protective numbness of mitochondria, and anaerobic glycolysis, rather due to the mitochondrial impairment, characterize the entire time frame of apoptosis, from the early to the late phase, which mimics the development of AD (literal)

Prodotto di

• Basi molecolari della neurodegenerazione nella malattia di Alzheimer e nelle tauopatie. Utilizzo delle cellule staminali neurali per la comprensione dei processi di differenziamento, neurodegenerazione e neuroriparazione. (ME.P02.026.002) (Modulo)
• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)
• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)

Autore CNR

• ANTONELLA BOBBA (Persona)
• GIUSEPPINA AMADORO (Persona)
• ANNA ATLANTE (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosis in cerebellar granule cells." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIUSEPPINA AMADORO (Persona)
• ANTONELLA BOBBA (Persona)
• ANNA ATLANTE (Unità di personale interno)

Prodotto

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Basi molecolari della neurodegenerazione nella malattia di Alzheimer e nelle tauopatie. Utilizzo delle cellule staminali neurali per la comprensione dei processi di differenziamento, neurodegenerazione e neuroriparazione. (ME.P02.026.002) (Modulo)
• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Apoptosis (Rivista)

Insieme di parole chiave di

• Parole chiave di "Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosis in cerebellar granule cells." (Insieme di parole chiave)