Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization (Articolo in rivista)

Type
Label
  • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ng.3014 (literal)
Alternative label
  • Arking D.E.; Pulit S.L.; Crotti L.; Van Der Harst P.; Munroe P.B.; Koopmann T.T.; Sotoodehnia N.; Rossin E.J.; Morley M.; Wang X.; Johnson A.D.; Lundby A.; Gudbjartsson D.F.; Noseworthy P.A.; Eijgelsheim M.; Bradford Y.; Tarasov K.V.; Dorr M.; Muller-Nurasyid M.; Lahtinen A.M.; Nolte I.M.; Smith A.V.; Bis J.C.; Isaacs A.; Newhouse S.J.; Evans D.S.; Post W.S.; Waggott D.; Lyytikainen L.-P.; Hicks A.A.; Eisele L.; Ellinghaus D.; Hayward C.; Navarro P.; Ulivi S.; Tanaka T.; Tester D.J.; Chatel S.; Gustafsson S.; Kumari M.; Morris R.W.; Naluai A.T.; Padmanabhan S.; Kluttig A.; Strohmer B.; Panayiotou A.G.; Torres M.; Knoflach M.; Hubacek J.A.; Slowikowski K.; Raychaudhuri S.; Kumar R.D.; Harris T.B.; Launer L.J.; Shuldiner A.R.; Alonso A.; Bader J.S.; Ehret G.; Huang H.; Kao W.H.L.; Strait J.B.; Macfarlane P.W.; Brown M.; Caulfield M.J.; Samani N.J.; Kronenberg F.; Willeit J.; Smith J.G.; Greiser K.H.; Zu Schwabedissen H.M.; Werdan K.; Carella M.; Zelante L.; Heckbert S.R.; Psaty B.M.; Rotter J.I.; Kolcic I.; Polasek O.; Wright A.F.; Griffin M.; Daly M.J.; Arnar D.O.; Holm H.; Thorsteinsdottir U.; Denny J.C.; Roden D.M.; Zuvich R.L.; Emilsson V.; Plump A.S.; Larson M.G.; O'Donnell C.J.; Yin X.; Bobbo M.; D'Adamo A.P.; Iorio A.; Sinagra G.; Carracedo A.; Cummings S.R.; Nalls M.A.; Jula A.; Kontula K.K.; Marjamaa A.; Oikarinen L.; Perola M.; Porthan K.; Erbel R.; Hoffmann P.; Jockel K.-H.; Kalsch H.; Nothen M.M.; Den Hoed M.; Loos R.J.F.; Thelle D.S.; Gieger C.; Meitinger T.; Perz S.; Peters A.; Prucha H.; Sinner M.F.; Waldenberger M.; De Boer R.A.; Franke L.; Van Der Vleuten P.A.; Beckmann B.M.; Martens E.; Bardai A.; Hofman N.; Wilde A.A.M.; Behr E.R.; Dalageorgou C.; Giudicessi J.R.; Medeiros-Domingo A.; Barc J.; Kyndt F.; Probst V.; Ghidoni A.; Insolia R.; Hamilton R.M.; Scherer S.W.; Brandimarto J.; Margulies K.; Moravec C.E.; Del Greco M F.; Fuchsberger C.; O'Connell J.R.; Lee W.K.; Watt G.C.M.; Campbell H.; Wild S.H.; El Mokhtari N.E.; Frey N.; Asselbergs F.W.; Leach I.M.; Navis G.; Van Den Berg M.P.; Van Veldhuisen D.J.; Kellis M.; Krijthe B.P.; Franco O.H.; Hofman A.; Kors J.A.; Uitterlinden A.G.; Witteman J.C.M.; Kedenko L.; Lamina C.; Oostra B.A.; Abecasis G.R.; Lakatta E.G.; Mulas A.; Orru M.; Schlessinger D.; Uda M.; Markus M.R.P.; Volker U.; Snieder H.; Spector T.D.; Arnlov J.; Lind L.; Sundstrom J.; Syvanen A.-C.; Kivimaki M.; Kahonen M.; Mononen N.; Raitakari O.T.; Viikari J.S.; Adamkova V.; Kiechl S.; Brion M.; Nicolaides A.N.; Paulweber B.; Haerting J.; Dominiczak A.F.; Nyberg F.; Whincup P.H.; Hingorani A.D.; Schott J.-J.; Bezzina C.R.; Ingelsson E.; Ferrucci L.; Gasparini P.; Wilson J.F.; Rudan I.; Franke A.; Muhleisen T.W.; Pramstaller P.P.; Lehtimaki T.J.; Paterson A.D.; Parsa A.; Liu Y.; Van Duijn C.M.; Siscovick D.S.; Gudnason V.; Jamshidi Y.; Salomaa V.; Felix S.B.; Sanna S.; Ritchie M.D.; Stricker B.H.; Stefansson K.; Boyer L.A.; Cappola T.P.; Olsen J.V.; Lage K.; Schwartz P.J.; Kaab S.; Chakravarti A.; Ackerman M.J.; Pfeufer A.; De Bakker P.I.W.; Newton-Cheh C. (2014)
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
    in Nature genetics (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Arking D.E.; Pulit S.L.; Crotti L.; Van Der Harst P.; Munroe P.B.; Koopmann T.T.; Sotoodehnia N.; Rossin E.J.; Morley M.; Wang X.; Johnson A.D.; Lundby A.; Gudbjartsson D.F.; Noseworthy P.A.; Eijgelsheim M.; Bradford Y.; Tarasov K.V.; Dorr M.; Muller-Nurasyid M.; Lahtinen A.M.; Nolte I.M.; Smith A.V.; Bis J.C.; Isaacs A.; Newhouse S.J.; Evans D.S.; Post W.S.; Waggott D.; Lyytikainen L.-P.; Hicks A.A.; Eisele L.; Ellinghaus D.; Hayward C.; Navarro P.; Ulivi S.; Tanaka T.; Tester D.J.; Chatel S.; Gustafsson S.; Kumari M.; Morris R.W.; Naluai A.T.; Padmanabhan S.; Kluttig A.; Strohmer B.; Panayiotou A.G.; Torres M.; Knoflach M.; Hubacek J.A.; Slowikowski K.; Raychaudhuri S.; Kumar R.D.; Harris T.B.; Launer L.J.; Shuldiner A.R.; Alonso A.; Bader J.S.; Ehret G.; Huang H.; Kao W.H.L.; Strait J.B.; Macfarlane P.W.; Brown M.; Caulfield M.J.; Samani N.J.; Kronenberg F.; Willeit J.; Smith J.G.; Greiser K.H.; Zu Schwabedissen H.M.; Werdan K.; Carella M.; Zelante L.; Heckbert S.R.; Psaty B.M.; Rotter J.I.; Kolcic I.; Polasek O.; Wright A.F.; Griffin M.; Daly M.J.; Arnar D.O.; Holm H.; Thorsteinsdottir U.; Denny J.C.; Roden D.M.; Zuvich R.L.; Emilsson V.; Plump A.S.; Larson M.G.; O'Donnell C.J.; Yin X.; Bobbo M.; D'Adamo A.P.; Iorio A.; Sinagra G.; Carracedo A.; Cummings S.R.; Nalls M.A.; Jula A.; Kontula K.K.; Marjamaa A.; Oikarinen L.; Perola M.; Porthan K.; Erbel R.; Hoffmann P.; Jockel K.-H.; Kalsch H.; Nothen M.M.; Den Hoed M.; Loos R.J.F.; Thelle D.S.; Gieger C.; Meitinger T.; Perz S.; Peters A.; Prucha H.; Sinner M.F.; Waldenberger M.; De Boer R.A.; Franke L.; Van Der Vleuten P.A.; Beckmann B.M.; Martens E.; Bardai A.; Hofman N.; Wilde A.A.M.; Behr E.R.; Dalageorgou C.; Giudicessi J.R.; Medeiros-Domingo A.; Barc J.; Kyndt F.; Probst V.; Ghidoni A.; Insolia R.; Hamilton R.M.; Scherer S.W.; Brandimarto J.; Margulies K.; Moravec C.E.; Del Greco M F.; Fuchsberger C.; O'Connell J.R.; Lee W.K.; Watt G.C.M.; Campbell H.; Wild S.H.; El Mokhtari N.E.; Frey N.; Asselbergs F.W.; Leach I.M.; Navis G.; Van Den Berg M.P.; Van Veldhuisen D.J.; Kellis M.; Krijthe B.P.; Franco O.H.; Hofman A.; Kors J.A.; Uitterlinden A.G.; Witteman J.C.M.; Kedenko L.; Lamina C.; Oostra B.A.; Abecasis G.R.; Lakatta E.G.; Mulas A.; Orru M.; Schlessinger D.; Uda M.; Markus M.R.P.; Volker U.; Snieder H.; Spector T.D.; Arnlov J.; Lind L.; Sundstrom J.; Syvanen A.-C.; Kivimaki M.; Kahonen M.; Mononen N.; Raitakari O.T.; Viikari J.S.; Adamkova V.; Kiechl S.; Brion M.; Nicolaides A.N.; Paulweber B.; Haerting J.; Dominiczak A.F.; Nyberg F.; Whincup P.H.; Hingorani A.D.; Schott J.-J.; Bezzina C.R.; Ingelsson E.; Ferrucci L.; Gasparini P.; Wilson J.F.; Rudan I.; Franke A.; Muhleisen T.W.; Pramstaller P.P.; Lehtimaki T.J.; Paterson A.D.; Parsa A.; Liu Y.; Van Duijn C.M.; Siscovick D.S.; Gudnason V.; Jamshidi Y.; Salomaa V.; Felix S.B.; Sanna S.; Ritchie M.D.; Stricker B.H.; Stefansson K.; Boyer L.A.; Cappola T.P.; Olsen J.V.; Lage K.; Schwartz P.J.; Kaab S.; Chakravarti A.; Ackerman M.J.; Pfeufer A.; De Bakker P.I.W.; Newton-Cheh C. (literal)
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  • Center for Complex Disease Genomics, Johns Hopkins University, School of Medicine, Baltimore, MD, United States; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, United States; Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, Netherlands; Department of Molecular Medicine, Section of Cardiology, University of Pavia, Pavia, Italy; Center for Cardiac Arrhythmias of Genetic Origin, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Clinical Pharmacology, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom; Barts and the London Genome Centre, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom; Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, Netherlands; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States; Cardiology Division, University of Washington, Seattle, WA, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Broad Institute of MIT and Harvard, Cambridge, MA, United States; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, United States; National Heart,Lung,and Blood Institute (NHLBI) Framingham Heart Study, Framingham, MA, United States; Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States; Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands; Center for Human Genetics Research, Vanderbilt University, School of Medicine, Nashville, TN, United States; Laboratory of Cardiovascular Sciences, Human Cardiovascular Studies Unit, National Institute on Aging, Baltimore, MD, United States; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research),Partner site Greifswald, Greifswald, Germany; Department of Medicine I, University Hospital Munich, Ludwig Maximilians Universität, Munich, Germany; Institute of Medical Informatics,Biometry and Epidemiology, Department of Epidemiology, Ludwig Maximilians Universität, Munich, Germany; Institute of Genetic Epidemiology, Helmholtz Zentrum Munich-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics,Biometry and Epidemiology, Department of Genetic Epidemiology, Ludwig Maximilians Universität, Munich, Germany; DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany; Research Programs Unit, Molecular Medicine, University of Helsinki, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Icelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands; California Pacific Medical Center Research Institute, San Francisco, CA, United States; Division of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States; Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, United States; Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere, School of Medicine, Tampere, Finland; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy; Institute for Medical Informatics,Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany; Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom; Institute for Maternal and Child Health, Burlo Garofolo Trieste, Trieste, Italy; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, United States; Department of Pediatrics, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, United States; Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States; Institut du Thorax, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France; Institut du Thorax, INSERM UMR1077, Université de Nantes, Nantes, France; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Institute of Cardiovascular Science, University College London, London, United Kingdom; Department of Primary Care and Population Health, University College London, Royal Free Campus, London, United Kingdom; Department of Medical and Clinical Genetics, Sahlgrenska Academy, University of Gothenburg, Gothenburge, Sweden; Biobanking and Molecular Resource Infrastructure of Sweden (BBMRI), Gothenburge, Sweden; BHF Glasgow Cardiovascular Research Centre, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Institute of Medical Epidemiology,Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle, Germany; Second Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria; Cyprus International Institute for Environmental and Public Health in association, Harvard School of Public Health, Cyprus University of Technology, Limassol, Cyprus; Cyprus Cardiovascular and Educational Research Trust, Nicosia, Cyprus; Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Department of Neurology, Innsbruck Medical University, Innsbruck, Austria; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Harvard Bioinformatics and Integrative Genomics, Boston, MA, United States; Partners HealthCare Center for Personalized Genetic Medicine, Boston, MA, United States; Division of Rheumatology,Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, United States; Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom; Computational and Systems Biology Program, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MI, United States; Department of Medicine, Washington University, School of Medicine, St. Louis, MI, United States; Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD, United States; Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, United States; Program for Personalized and Genomic Medicine, University of Maryland, Baltimore, MD, United States; Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, MD, United States; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, United States; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; Electrocardiology, University of Glasgow Institute of Cardiovascular and Medical Sciences, Royal Infirmary, Glasgow, United Kingdom; Clinical Pharmacology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Cardiovascular Science, University of Leicester, Glenfield Hospital, Leicester, United Kingdom; Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria; Department of Cardiology, Lund University, Lund, Sweden; Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany; Department of Pharmacology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany; Department of Medicine III, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle, Germany; Medical Genetics Unit, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; Department of Epidemiology, University of Washington, Seattle, WA, United States; Department of Health Services, University of Washington, Seattle, WA, United States; Group Health Research Institute, Group Health Cooperative, Seattle, WA, United States; Department of Medicine, University of Washington, Seattle, WA, United States; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-University of California, Torrance, CA, United States; Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia; Vascular Screening and Diagnostic Centre, London, United Kingdom; Department of Medicine, Division of Cardiology, Landspitali University Hospital, Reykjavik, Iceland; Department of Biomedical Informatics, Vanderbilt University, School of Medicine, Nashville, TN, United States; Department of Medicine, Vanderbilt University, School of Medicine, Nashville, TN, United States; Department of Pharmacology, Vanderbilt University, Nashville, TN, United States; Office of Personalized Medicine, Vanderbilt University, Nashville, TN, United States; Sanofi Research and Development, Paris, France; Department of Biostatistics, Boston University, School of Public Health, Boston, MA, United States; Department of Mathematics and Statistics, Boston University, Boston, MA, United States; Cardiology Division, Massachusetts General Hospital, Boston, MA, United States; Cardiovascular Department, Ospedali Riuniti and University of Trieste, Trieste, Italy; Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy; Fundación Publica Galega de Medicina Xenómica, Servicio Galego de Saude, Santiago de Compostela, Spain; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia; Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, MD, United States; Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Medicine, University of Helsinki, Helsinki, Finland; Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland; Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Estonian Genome Center, University of Tartu, Tartu, Estonia; Department of Cardiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; Institute of Human Genetics, University of Bonn, Bonn, Germany; Division of Medical Genetics, University Hospital Basel, Basel, Switzerland; Department of Biomedicine, University of Basel, Basel, Switzerland; MRC Epidemiology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Department of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburge, Sweden; Institute of Human Genetics, Technische Universität München, Munich, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute for Biological and Medical Imaging, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Christine Kühne-Center for Allergy and Education, Munich, Germany; Department of Dermatology and Allergy, Technische Universität München, Munich, Germany; Department of Medicine, Hospital of Friedberg, Friedberg, Germany; Department of Clinical Genetics, Academic Medical Center, Amsterdam, Netherlands; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia; Cardiovascular and Cell Sciences Institute, St George's University of London, London, United Kingdom; Biomedical Sciences, St George's University of London, London, United Kingdom; Labatt Family Heart Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada; Centre for Applied Genomics, Hospital for Sick Children, Toronto, ON, Canada; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States; General Practice and Primary Care, University of Glasgow, Glasgow, United Kingdom; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom; Biobank PopGen, Institute of Experimental Medicine, Christian Albrechts University of Kiel, Kiel, Germany; Department of Internal Medicine III, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of The Netherlands, Netherlands Heart Institute, Utrecht, Netherlands; Department of Cardiology, Division of Heart and Lungs, University Medical Centre Utrecht, Utrecht, Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Netherlands Consortium for Healthy Aging (NCHA), Leiden, Netherlands; Department of Medical Informatics, Erasmus Medical Center, Rotterdam, Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy; Intramural Research Program, National Institute on Aging, US National Institutes of Health, Baltimore, MD, United States; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University Greifswald, Greifswald, Germany; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom; School of Health and Social Sciences, Dalarna University, Falun, Sweden; Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Department of Clinical Physiology, University of Tampere, School of Medicine, Tampere, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Medicine, Turku University Hospital, University of Turku, Turku, Finland; Xenética de Enfermidades Cardiovasculares e Oftalmolóxicas, Complexo Hospitalario Universitario de Santiago de Compostela, Servicio Galego de Saude, Santiago de Compostela, Spain; Global Epidemiology, AstraZeneca Research and Development, Mölndal, Sweden; Division of Population Health Sciences and Education, St George's University of London, London, United Kingdom; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Juelich, Juelich, Germany; Department of Neurology, University of Lübeck, Lübeck, Germany; Department of Neurology, General Central Hospital, Bolzano, Italy; Genetics and Genome Biology Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC, United States; Human Genetics Research Centre, St George's University of London, London, United Kingdom; Center for Systems Genomics, Pennsylvania State University, University Park, PA, United States; Inspectorate of Health Care, The Hague, Netherlands; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark; Pediatric Surgical Research Laboratories, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, MA, United States; Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States; Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum, Munich, Germany; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands (literal)
Titolo
  • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization (literal)
Abstract
  • The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ~ 8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD. © 2014 Nature America, Inc. (literal)
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