Gene-age interactions in blood pressure regulation: A large-scale investigation with the CHARGE, global BPgen, and ICBP consortia (Articolo in rivista)

Type
Label
  • Gene-age interactions in blood pressure regulation: A large-scale investigation with the CHARGE, global BPgen, and ICBP consortia (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ajhg.2014.05.010 (literal)
Alternative label
  • Simino J.; Shi G.; Bis J.C.; Chasman D.I.; Ehret G.B.; Gu X.; Guo X.; Hwang S.-J.; Sijbrands E.; Smith A.V.; Verwoert G.C.; Bragg-Gresham J.L.; Cadby G.; Chen P.; Cheng C.-Y.; Corre T.; De Boer R.A.; Goel A.; Johnson T.; Khor C.-C.; Lluis-Ganella C.; Luan J.; Lyytikainen L.-P.; Nolte I.M.; Sim X.; Sober S.; Van Der Most P.J.; Verweij N.; Zhao J.H.; Amin N.; Boerwinkle E.; Bouchard C.; Dehghan A.; Eiriksdottir G.; Elosua R.; Franco O.H.; Gieger C.; Harris T.B.; Hercberg S.; Hofman A.; James A.L.; Johnson A.D.; Kahonen M.; Khaw K.-T.; Kutalik Z.; Larson M.G.; Launer L.J.; Li G.; Liu J.; Liu K.; Morrison A.C.; Navis G.; Ong R.T.-H.; Papanicolau G.J.; Penninx B.W.; Psaty B.M.; Raffel L.J.; Raitakari O.T.; Rice K.; Rivadeneira F.; Rose L.M.; Sanna S.; Scott R.A.; Siscovick D.S.; Stolk R.P.; Uitterlinden A.G.; Vaidya D.; Van Der Klauw M.M.; Vasan R.S.; Vithana E.N.; Volker U.; Volzke H.; Watkins H.; Young T.L.; Aung T.; Bochud M.; Farrall M.; Hartman C.A.; Laan M.; Lakatta E.G.; Lehtimaki T.; Loos R.J.F.; Lucas G.; Meneton P.; Palmer L.J.; Rettig R.; Snieder H.; Tai E.S.; Teo Y.-Y.; Van Der Harst P.; Wareham N.J.; Wijmenga C.; Wong T.Y.; Fornage M.; Gudnason V.; Levy D.; Palmas W.; Ridker P.M.; Rotter J.I.; Van Duijn C.M.; Witteman J.C.M.; Chakravarti A.; Rao D.C. (2014)
    Gene-age interactions in blood pressure regulation: A large-scale investigation with the CHARGE, global BPgen, and ICBP consortia
    in American journal of human genetics
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Simino J.; Shi G.; Bis J.C.; Chasman D.I.; Ehret G.B.; Gu X.; Guo X.; Hwang S.-J.; Sijbrands E.; Smith A.V.; Verwoert G.C.; Bragg-Gresham J.L.; Cadby G.; Chen P.; Cheng C.-Y.; Corre T.; De Boer R.A.; Goel A.; Johnson T.; Khor C.-C.; Lluis-Ganella C.; Luan J.; Lyytikainen L.-P.; Nolte I.M.; Sim X.; Sober S.; Van Der Most P.J.; Verweij N.; Zhao J.H.; Amin N.; Boerwinkle E.; Bouchard C.; Dehghan A.; Eiriksdottir G.; Elosua R.; Franco O.H.; Gieger C.; Harris T.B.; Hercberg S.; Hofman A.; James A.L.; Johnson A.D.; Kahonen M.; Khaw K.-T.; Kutalik Z.; Larson M.G.; Launer L.J.; Li G.; Liu J.; Liu K.; Morrison A.C.; Navis G.; Ong R.T.-H.; Papanicolau G.J.; Penninx B.W.; Psaty B.M.; Raffel L.J.; Raitakari O.T.; Rice K.; Rivadeneira F.; Rose L.M.; Sanna S.; Scott R.A.; Siscovick D.S.; Stolk R.P.; Uitterlinden A.G.; Vaidya D.; Van Der Klauw M.M.; Vasan R.S.; Vithana E.N.; Volker U.; Volzke H.; Watkins H.; Young T.L.; Aung T.; Bochud M.; Farrall M.; Hartman C.A.; Laan M.; Lakatta E.G.; Lehtimaki T.; Loos R.J.F.; Lucas G.; Meneton P.; Palmer L.J.; Rettig R.; Snieder H.; Tai E.S.; Teo Y.-Y.; Van Der Harst P.; Wareham N.J.; Wijmenga C.; Wong T.Y.; Fornage M.; Gudnason V.; Levy D.; Palmas W.; Ridker P.M.; Rotter J.I.; Van Duijn C.M.; Witteman J.C.M.; Chakravarti A.; Rao D.C. (literal)
Pagina inizio
  • 24 (literal)
Pagina fine
  • 38 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84904067016&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 95 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, United States; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, United States; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, United States; Harvard Medical School, Boston, MA 02115, United States; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, Geneva 1211, Switzerland; Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, United States; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, United States; Framingham Heart Study, Framingham, MA 01702, United States; Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, United States; Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, Netherlands; Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland; Department of Epidemiology, Erasmus University Medical Center, 015 GE Rotterdam, Netherlands; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, United States; Centre for Genetic Origins of Health and Disease, University of Western Australia, Nedlands, WA 6009, Australia; Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore; Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom; Clinical Pharmacology, Barts and London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Paediatrics, National University Health System, Singapore 119074, Singapore; Cardiovascular Epidemiology and Genetics, IMIM (Hospital Del Mar Medical Research Institute), 08003 Barcelona, Spain; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 30101, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33101, Finland; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands; Centre for Molecular Epidemiology, National University of Singapore, Singapore 119260, Singapore; Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia; Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, United States; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States; Epidemiology and Public Health Network (CIBERESP), 08036 Barcelona, Spain; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany; Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, United States; U557 Institut National de la Santé et de la Recherche Médicale, U1125 Institut National de la Recherche Agronomique, Université Paris 13, 93000 Bobigny, France; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia; Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, United States; Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33521, Finland; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, United Kingdom; Department of Mathematics, Boston University, Boston, MA 02215, United States; Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, United States; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, United States; Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, Netherlands; Department of Psychiatry, Leiden University Medical Centre, 2333 ZD Leiden, Netherlands; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands; Department of Epidemiology, University of Washington, Seattle, WA 98195, United States; Department of Health Services, University of Washington, Seattle, WA 98195, United States; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, United States; Medical Genetics Institute, Cedars-Sinai Medical Center, Pacific Theatres, Los Angeles, CA 90048, United States; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20521, Finland; Department of Biostatistics, University of Washington, Seattle, WA 98195, United States; Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato 09042, Italy; Netherland Genomics Inititiative, Netherlands Center for Healthy Aging, The Hague 2509, Netherlands; Department of Medicine, Johns Hopkins University, Baltimore, MD 21202, United States; Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands; Divisions of Epidemiology and Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, United States; Neuroscience and Behavioural Disorders (NBD) Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore; Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17487 Greifswald, Germany; Institute for Community Medicine, University of Greifswald, 17487 Greifswald, Germany; Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, United States; Division of Neuroscience, Duke-National University of Singapore, Singapore 169857, Singapore; Institute of Social and Preventive Medicine, Lausanne University Hospital, 1010 Lausanne, Switzerland; Interdisciplinary Center for Pathology of Emotions, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Bethesda, MD 21224, United States; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Paris 75006, France; Institute of Physiology, University of Greifswald, 17495 Karlsburg, Germany; Department of Medicine, National University Health System and Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Duke-National University of Singapore, Graduate Medical School, Singapore 169857, Singapore; Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117543, Singapore; Genome Institute of Singapore, ASTAR, Singapore 138672, Singapore; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands; Durrer Center for Cardiogenetic Research, 3501 DG Utrecht, Netherlands; Boston University School of Medicine, Boston, MA 02118, United States; Department of Medicine, Columbia University, New York, NY 10032, United States; Netherland Genomics Initiative, Centre for Medical Systems Biology, 2300 RC Leiden, Netherlands; Departments of Psychiatry, Genetics, and Mathematics, Washington University School of Medicine, St. Louis, MO 63110, United States (literal)
Titolo
  • Gene-age interactions in blood pressure regulation: A large-scale investigation with the CHARGE, global BPgen, and ICBP consortia (literal)
Abstract
  • Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard approach (age stratification and metaregression) to conduct a genome-wide search of common variants with age-dependent effects on systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse (PP) pressure. In a two-staged design using 99,241 individuals of European ancestry, we identified 20 genome-wide significant (p<= 5 10) loci by using joint tests of the SNP main effect and SNP-age interaction. Nine of the significant loci demonstrated nominal evidence of age-dependent effects on BP by tests of the interactions alone. Index SNPs in the EHBP1L1 (DBP and MAP), CASZ1 (SBP and MAP), and GOSR2 (PP) loci exhibited the largest age interactions, with opposite directions of effect in the young versus the old. The changes in the genetic effects over time were small but nonnegligible (up to 1.58 mm Hg over 60 years). The EHBP1L1 locus was discovered through gene-age interactions only in whites but had DBP main effects replicated (p = 8.3 10) in 8,682 Asians from Singapore, indicating potential interethnic heterogeneity. A secondary analysis revealed 22 loci with evidence of age-specific effects (e.g., only in 20 to 29-year-olds). Age can be used to select samples with larger genetic effect sizes and more homogenous phenotypes, which may increase statistical power. Age-dependent effects identified through novel statistical approaches can provide insight into the biology and temporal regulation underlying BP associations. © 2014 The American Society of Human Genetics. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it