The unique ligand binding features of subfamily-II iLBPs with respect to bile salts and related drugs (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The unique ligand binding features of subfamily-II iLBPs with respect to bile salts and related drugs (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.plefa.2014.10.005 (literal)

Alternative label

• Favretto F.; Ceccon A.; Zanzoni S.; D'Onofrio M.; Ragona L.; Molinari H.; Assfalg M. (2014)
  The unique ligand binding features of subfamily-II iLBPs with respect to bile salts and related drugs
  in Prostaglandins, leukotrienes and essential fatty acids
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Favretto F.; Ceccon A.; Zanzoni S.; D'Onofrio M.; Ragona L.; Molinari H.; Assfalg M. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84914141873&partnerID=q2rCbXpz (literal)

Rivista

• Prostaglandins, leukotrienes and essential fatty acids (Rivista)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Biotechnology, University of Verona, Strada Le Grazie 15, Verona 37134, Italy; Institute for Macromolecular Studies, National Research Council, Via Bassini 15, Milan 20133, Italy (literal)

Titolo

• The unique ligand binding features of subfamily-II iLBPs with respect to bile salts and related drugs (literal)

Abstract

• Intracellular lipid binding proteins (iLBPs) are a family of evolutionarily related small cytoplasmic proteins implicated in the transcellular transport of lipophilic ligands. Subfamily-II iLBPs include the liver fatty acid binding protein (L-FABP), and the ileal and the liver and ileal bile acid binding proteins (L-BABP and I-BABP). Atomic-level investigations during the past 15-20 years have delivered relevant information on bile acid binding by this protein group, revealing unique features including binding cooperativity, promiscuity, and site selectivity. Using NMR spectroscopy and other biophysical techniques, our laboratories have contributed to an understanding of the molecular determinants of some of these properties and their generality among proteins from different animal species. We focused especially on formation of heterotypic complexes, considering the mixed compositions of physiological bile acid pools. Experiments performed with synthetic bile acid derivatives showed that iLBPs could act as targets for cell-specific contrast agents and, more generally, as effective carriers of amphiphilic drugs. This review collects the major findings related to bile salt interactions with iLBPs aiming to provide keys for a deeper understanding of protein-mediated intracellular bile salt trafficking. (literal)

Prodotto di

• Strutturistica NMR di proteine legate a processi patologici (PM.P01.026.003) (Modulo)
• Istituto per lo studio delle macromolecole (ISMAC) (Istituto)

Autore CNR

• LAURA GIUDITTA RAGONA (Unità di personale interno)
• HENRIETTE MOLINARI (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "The unique ligand binding features of subfamily-II iLBPs with respect to bile salts and related drugs" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto per lo studio delle macromolecole (ISMAC) (Istituto)
• Strutturistica NMR di proteine legate a processi patologici (PM.P01.026.003) (Modulo)

Autore CNR di

• LAURA GIUDITTA RAGONA (Unità di personale interno)
• HENRIETTE MOLINARI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Prostaglandins, leukotrienes and essential fatty acids (Rivista)

Insieme di parole chiave di

• Keywords of "The unique ligand binding features of subfamily-II iLBPs with respect to bile salts and related drugs" (Insieme di parole chiave)