Improved osteoblast cell affinity on plasma-modified 3D extruded PCL scaffolds (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Improved osteoblast cell affinity on plasma-modified 3D extruded PCL scaffolds (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Alternative label

• M. Domingos a, F. Intranuovo b, A. Gloria c, R. Gristina d, L. Ambrosio c, P.J. Bártolo a, P. Favia b,d (2013)
  Improved osteoblast cell affinity on plasma-modified 3D extruded PCL scaffolds
  in Acta biomaterialia
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• M. Domingos a, F. Intranuovo b, A. Gloria c, R. Gristina d, L. Ambrosio c, P.J. Bártolo a, P. Favia b,d (literal)

Pagina inizio

• 5997 (literal)

Pagina fine

• 6005 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• Acta biomaterialia (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Portugal b Department of Chemistry, University of Bari, Italy c Institute of Composite and Biomedical Materials, National Research Council, Naples, Italy d Institute of Inorganic Methodologies and Plasmas, National Research Council, Bari, Italy (literal)

Titolo

• Improved osteoblast cell affinity on plasma-modified 3D extruded PCL scaffolds (literal)

Abstract

• Cellular adhesion and proliferation inside three-dimensional synthetic scaffolds represent a major chal- lenge in tissue engineering. Besides the surface chemistry of the polymers, it is well recognized that scaf- fold internal architecture, namely pore size/shape and interconnectivity, has a strong effect on the biological response of cells. This study reports for the first time how polycaprolactone (PCL) scaffolds with controlled micro-architecture can be effectively produced via bioextrusion and used to enhance the penetration of plasma deposited species. Low-pressure nitrogen-based coatings were employed to augment cell adhesion and proliferation without altering the mechanical properties of the structures. X-ray photoelectron spectroscopy carried out on different sections of the scaffolds indicates a uniform distribution of nitrogen-containing groups throughout the entire porous structure. In vitro biological assays confirm that plasma deposition sensitively promotes the activity of Saos-2 osteoblast cells, leading to a homogeneous colonization of the PCL scaffolds. (literal)

Prodotto di

• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)
• Institute for composite and biomedical materials (IMCB) (Istituto)

Autore CNR

• LUIGI AMBROSIO (Unità di personale interno)
• ANTONIO GLORIA (Unità di personale interno)

Incoming links:

Prodotto

• Institute for composite and biomedical materials (IMCB) (Istituto)
• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)

Autore CNR di

• LUIGI AMBROSIO (Unità di personale interno)
• ANTONIO GLORIA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Acta biomaterialia (Rivista)