http://www.cnr.it/ontology/cnr/individuo/prodotto/ID290079

Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.3748/wjg.v20.i45.17107 (literal)

Alternative label

1)Lucia Pacifico, 2)Enea Bonci, 2)Lidia Marandola,1) Sara Romaggioli, 1)Stefano Bascetta, 3)Claudio Chiesa (2014)
Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease
in World journal of gastroenterology (Online)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

1)Lucia Pacifico, 2)Enea Bonci, 2)Lidia Marandola,1) Sara Romaggioli, 1)Stefano Bascetta, 3)Claudio Chiesa (literal)

Pagina inizio

17107 (literal)

Pagina fine

17114 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

20 (literal)

Rivista

World journal of gastroenterology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

45 (literal)

Note

ubMe (literal)
ISI Web of Science (WOS) (literal)
Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1)Department of Pediatrics and Child Neuropsychiatry, Sapienza University of Rome, 00161 Rome, Italy;2)Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy; Institute of Translational Pharmacology, National Research Council, 00133 Rome, Italy (literal)

Titolo

Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease (literal)

Abstract

AIM: To investigate the potential association of circulating zonulin with the stage of liver disease in obese children with biopsy-confirmed nonalcoholic fatty liver disease (NAFLD). METHODS: A case-control study was performed. Cases were 40 obese children with NAFLD. The diagnosis of NAFLD was based on magnetic resonance imaging (MRI) with high hepatic fat fraction (HFF >= 5%), and confirmed by liver biopsy with >= 5% of hepatocytes containing macrovesicular fat. Controls were selected from obese children with normal levels of aminotransferases, and without MRI evidence of fatty liver as well as of other causes of chronic liver diseases. Controls were matched (1-to 1) with the cases on age, gender, pubertal stage and as closely as possible on body mass index- standard deviation score. All participants underwent clinical examination, laboratory tests including zonulin, inflammatory and metabolic parameters, and MRI for measurement of HFF and visceral adipose tissue. RESULTS: Zonulin values were significantly greater in obese subjects with NAFLD than in those without NAFLD [median (interquartile range), 4.23 (3.18-5.89) vs 3.31 (2.05-4.63), P < 0.01]. In patients with NAFLD, zonulin concentrations increased significantly with the severity of steatosis and the Spearman's coefficient revealed a positive correlation between zonulin values and steatosis (r = 0.372, P < 0.05); however, we did not find a significant correlation between zonulin and lobular inflammation (P = 0.23), ballooning (P = 0.10), fibrosis score (P = 0.18), or presence of nonalcoholic steatohepatitis (P = 0.17). Within the entire study population, zonulin levels were positively associated with gamma-glutamyl transferase, 2-h insulin, HFF, and negatively associated with whole-body insulin sensitivity index (WBISI), after adjustment for age, gender and pubertal status. When the associations were restricted to the group of NAFLD patients, 2-h insulin, hepatic fat, and WBISI retained statistical significance. CONCLUSION: Circulating zonulin is increased in children and adolescents with NAFLD and correlates with the severity of steatosis. (literal)

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