Circulating endocannabinoids in insulin sensitive vs. Insulin resistant obese postmenopausal women. A MONET group study (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Circulating endocannabinoids in insulin sensitive vs. Insulin resistant obese postmenopausal women. A MONET group study (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/oby.20498 (literal)

Alternative label

• Abdulnour J.; Yasari S.; Rabasa-Lhoret R.; Faraj M.; Petrosino S.; Piscitelli F.; Prud'Homme D.; Di Marzo V. (2014)
  Circulating endocannabinoids in insulin sensitive vs. Insulin resistant obese postmenopausal women. A MONET group study
  in Obesity (Silver Spring, Md.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Abdulnour J.; Yasari S.; Rabasa-Lhoret R.; Faraj M.; Petrosino S.; Piscitelli F.; Prud'Homme D.; Di Marzo V. (literal)

Pagina inizio

• 211 (literal)

Pagina fine

• 216 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84892364262&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Obesity (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• School of Human Kinetics Faculty of Health Science, University of Ottawa, Ottawa, ON, Canada; Behavioural and Metabolic Research Unit, University of Ottawa, Ottawa, ON, Canada; PROMD Platfrom for Research in Obesity Metabolism and Diabetes, Montreal Institute for Clinical Research (IRCM), Montreal, QC, Canada; Nutrition Department Faculty of Medecine, Université de Montréal, Montréal, QC, Canada; Endocannabinoid Research Group Institute of Biomolecular Chemistry, Consiglio Nazionale Delle Ricerche NA, Via Campi Flegrei 34, Comprensorio Olivetti, Pozzuoli 80078, Italy (literal)

Titolo

• Circulating endocannabinoids in insulin sensitive vs. Insulin resistant obese postmenopausal women. A MONET group study (literal)

Abstract

• OBJECTIVE: To measure the circulating levels of endocannabinoids and related molecules at fasting, after acute hyperinsulinemia and after weight loss in insulin sensitive vs. insulin resistant obese postmenopausal women. DESIGN AND METHODS: The sample consisted of 30 obese postmenopausal women (age: 58.9 ± 5.2 yrs; BMI: 32.9 ± 3.6 kg/m(2) ). Subjects underwent a 3-hour hyperinsulinaemic-euglycaemic clamp (HEC) (glucose disposal rate (M-value): 10.7 ± 3.3 mg min(-1) kg(-1) FFM) and 6-month weight loss intervention. Participants were classified as insulin sensitive obese (ISO) or insulin resistant obese (IRO) based on a predefined cutoff. Plasma levels of the endocannabinoids, anandamide (AEA), 2-arachidonoylglycerol (2-AG), and of the AEA-related compounds, palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), were measured by liquid chromatography-mass spectrometry. RESULTS: IRO presented higher levels of 2-AG (P < 0.05) independently of the HEC and weight loss, whereas the HEC had an independent inhibitory effect on AEA, PEA, and OEA levels (P < 0.05) in both groups. Furthermore, there was an independent stimulatory effect of weight loss only on PEA levels in both groups (P < 0.05). CONCLUSIONS: This study is the first to show that higher circulating levels of the endocannabinoid 2-AG are found in IRO compared to ISO postmenopausal women, and that weight loss is associated with an increase in PEA, a PPAR-? ligand. (literal)

Prodotto di

• Struttura, funzione e \"profiling\" di endocannabinoidi e ammidi bioattive di acidi grassi implicati nelle patologie umane (PM.P01.012.001) (Modulo)
• Istituto di chimica biomolecolare (ICB) (Istituto)

Autore CNR

• STEFANIA PETROSINO (Unità di personale esterno)
• VINCENZO DI MARZO (Unità di personale interno)
• FABIANA PISCITELLI (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Struttura, funzione e \"profiling\" di endocannabinoidi e ammidi bioattive di acidi grassi implicati nelle patologie umane (PM.P01.012.001) (Modulo)

Autore CNR di

• VINCENZO DI MARZO (Unità di personale interno)
• STEFANIA PETROSINO (Unità di personale esterno)
• FABIANA PISCITELLI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Obesity (Rivista)