Gene Therapy: The Role of Cytoskeleton in Gene Transfer Studies Based on Biology and Mathematics (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Gene Therapy: The Role of Cytoskeleton in Gene Transfer Studies Based on Biology and Mathematics (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2174/1566523214666140305223251 (literal)

Alternative label

• Notarangelo, Maria G.; Natalini, Roberto; Signori, Emanuela (2014)
  Gene Therapy: The Role of Cytoskeleton in Gene Transfer Studies Based on Biology and Mathematics
  in Current gene therapy (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Notarangelo, Maria G.; Natalini, Roberto; Signori, Emanuela (literal)

Pagina inizio

• 121 (literal)

Pagina fine

• 127 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 14 (literal)

Rivista

• Current gene therapy (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Sapienza University Rome; Consiglio Nazionale delle Ricerche (CNR); Consiglio Nazionale delle Ricerche (CNR); University Campus Bio-Medico - Rome Italy (literal)

Titolo

• Gene Therapy: The Role of Cytoskeleton in Gene Transfer Studies Based on Biology and Mathematics (literal)

Abstract

• Gene therapy is a promising approach for treating a wide range of human pathologies such as genetic disorders as well as diseases acquired over time. Viral and non-viral vectors are used to convey sequences of genes that can be expressed for therapeutic purposes. Plasmid DNA is receiving considerable attention for intramuscular gene transfer due to its safety, simplicity and low cost of production. Nevertheless, strategies to improve DNA uptake into the nucleus of cells for its expression are required. Cytoskeleton plays an important role in the intracellular trafficking. The mechanism regulating this process must be elucidated. Here, we propose a new methodological approach based on the coupling of biology assays and predictive mathematical models, in order to clarify the mechanism of the DNA uptake and its expression into the cells. Once these processes are better clarified, we will be able to propose more efficient therapeutic gene transfer protocols for the treatment of human patients. (literal)

Prodotto di

• Trasmissione di segnali intracellulari (INT.P02.004.002) (Modulo)
• Istituto per le applicazioni del calcolo \"Mauro Picone\" (IAC) (Istituto)

Autore CNR

• EMANUELA SIGNORI (Unità di personale interno)
• ROBERTO NATALINI (Persona)

Insieme di parole chiave

• Keywords of "Gene Therapy: The Role of Cytoskeleton in Gene Transfer Studies Based on Biology and Mathematics" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• EMANUELA SIGNORI (Unità di personale interno)
• ROBERTO NATALINI (Persona)

Prodotto

• Istituto per le applicazioni del calcolo \"Mauro Picone\" (IAC) (Istituto)
• Trasmissione di segnali intracellulari (INT.P02.004.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current gene therapy (Rivista)

Insieme di parole chiave di

• Keywords of "Gene Therapy: The Role of Cytoskeleton in Gene Transfer Studies Based on Biology and Mathematics" (Insieme di parole chiave)