In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2147/IJN.S61273 (literal)

Alternative label

• Baldi, Giovanni; Ravagli, Costanza; Mazzantini, Filippo; Loudos, George; Adan, Jaume; Masa, Marc; Psimadas, Dimitrios; Fragogeorgi, Eirini A.; Locatelli, Erica; Innocenti, Claudia; Sangregorio, Claudio; Franchini, Mauro Comes (2014)
  In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles
  in International journal of nanomedicine (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Baldi, Giovanni; Ravagli, Costanza; Mazzantini, Filippo; Loudos, George; Adan, Jaume; Masa, Marc; Psimadas, Dimitrios; Fragogeorgi, Eirini A.; Locatelli, Erica; Innocenti, Claudia; Sangregorio, Claudio; Franchini, Mauro Comes (literal)

Pagina inizio

• 3037 (literal)

Pagina fine

• 3056 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• International journal of nanomedicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 20 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CERICOL; Inst Educ Technol; Leitat Technol Ctr; University of Bologna; University of Florence; University of Florence; Consiglio Nazionale delle Ricerche (CNR) (literal)

Titolo

• In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles (literal)

Abstract

• Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D, L-lactide-co-glycolide)-b-poly(ethylene glycol)-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with Tc-99m and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with Tc-99m, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma. (literal)

Prodotto di

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Nanosistemi organizzati di magneti molecolari (PM.P05.012.001) (Modulo)
• Istituto di chimica dei composti organo metallici (ICCOM) (Istituto)

Autore CNR

• CLAUDIO SANGREGORIO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Istituto di chimica dei composti organo metallici (ICCOM) (Istituto)
• Nanosistemi organizzati di magneti molecolari (PM.P05.012.001) (Modulo)

Autore CNR di

• CLAUDIO SANGREGORIO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• International journal of nanomedicine (Rivista)

Insieme di parole chiave di

• Parole chiave di "In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles" (Insieme di parole chiave)